ReviewChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2011
Hydrocephalus associated with neural tube defects: characteristics, management, and outcome in sub-Saharan Africa.
Review in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Efficacy and safety of endoscopic third ventriculostomy and choroid plexus cauterization for infantile hydrocephalus: a systematic review and meta-analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Pooled it
- Endoscopic third ventriculostomy with/without choroid plexus cauterization for hydrocephalus due to hemorrhage, infection, Dandy-Walker malformation, and neural tube defect: a meta-analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2014Pooled it
- The top 100 most cited peer-reviewed publications on global neurosurgery: Mapping research trends and gaps over four decades.Acta neurochirurgica · 2026Review
- Treatment failure after endoscopic third ventriculostomy with choroid plexus cauterization, endoscopic third ventriculostomy alone, and ventriculoperitoneal shunt in congenital hydrocephalus: a network and time-to-event meta-analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- The burden of neural tube defects in Southern Ethiopia: trends, hotspots, and public health implications.PeerJ · 2026Article
- Occipital encephalocele: a retrospective analysis and assessment of post-surgical neurodevelopmental outcome.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Meningomyelocele Perioperative Management in Neonatal: Case Series.Children (Basel, Switzerland) · 2024Article
- [Occipital encephalocele and associated anomalies including bilateral eyelid coloboma, bilateral cleft lip/cleft palate, amniotic bands on the right leg with absence of toes on right and left feet at the University Clinics of Graben Butembo 2021: a case report].The Pan African medical journal · 2022Article
- Surgical Outcomes after Myelomeningocele Repair in Lusaka, Zambia.World neurosurgery · 2021Article
- Prenatal surgery for myelomeningocele: review of the literature and future directions.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Review
- Prenatal diagnosis and assessment of congenital spinal anomalies: Review for prenatal counseling.World journal of orthopedics · 2016Review
- Access to health care for children with neural tube defects: Experiences of mothers in Zambia.African journal of disability · 2016Article
- The Global Paediatric Surgery Network: a model of subspecialty collaboration within global surgery.World journal of surgery · 2015Article
- Hydrocephalus in children less than 1 year of age in northern Mozambique.Surgical neurology international · 2014Article
- Myelomeningocele: the management of the associated hydrocephalus.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2013Review
- Natural history of hydrocephalus in children with spinal open neural tube defect.Surgical neurology international · 2012Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe past decade has provided new insights into the causes and optimal treatment of infant hydrocephalus in sub-Saharan Africa. Here, I review what we have learned in East Africa about the characteristics, management, and outcomes of hydrocephalus associated with neural tube defects, with particular emphasis on its primary treatment by endoscopic third ventriculostomy combined with choroid plexus cauterization (ETV/CPC).
methodsNew data from an updated review of the CURE Children's Hospital clinical database is combined with previously published observations to summarize what we have learned to date.
resultsHydrocephalus associated with myelomeningocele (MM) accounted for 11.8% of 2,780 new cases of hydrocephalus reviewed, and that associated with encephalocele (EC) accounted for 0.5%. Treatment for hydrocephalus was required in 51% of infants with MM and 32% of those with EC. Aqueductal stenosis or obstruction was observed in 82.7% of patients with MM and 71% of those with EC. ETV/CPC successfully treated hydrocephalus without any further surgery in 76% of infants with MM and 80% of those with EC, and was superior to shunting in regard to the incidence of treatment failure, operative mortality, and infection. Shunting in MM infants has no apparent developmental advantage. Although 5-year mortality for infants with neural tube defects in Uganda is significantly greater than their unaffected peers, this appears to be dramatically reduced by the "observer effect" of community-based rehabilitation.
conclusionsPrimary management by ETV/CPC avoids the increased danger of shunt dependence in sub-Saharan Africa for most infants with hydrocephalus associated with neural tube defects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.