ArticleBehavior genetics2012
A multivariate twin study of autistic traits in 12-year-olds: testing the fractionable autism triad hypothesis.
Article in Behavior genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 86 citations in OpenAlex.
- Examining and interpreting the female protective effect against autistic behavior.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Shared genetic architecture between autism spectrum disorder, loneliness, and social isolation reveals novel genetic loci.Psychiatric genetics · 2026Article
- Research Review: A review of the past decade of family and genomic studies on adolescent mental health.Journal of child psychology and psychiatry, and allied disciplines · 2025Review
- Alexithymia may explain the genetic relationship between autism and sensory sensitivity.Translational psychiatry · 2025Article
- Profiles of autism characteristics in thirteen genetic syndromes: a machine learning approach.Molecular autism · 2023Article
- Evaluating causal psychological models: A study of language theories of autism using a large sample.Frontiers in psychology · 2023Article
- Variegation of autism related traits across seven neurogenetic disorders.Translational psychiatry · 2022Article
- The hallmarks of autism.Frontiers in psychiatry · 2022Article
- Comorbidity of Attention-Deficit Hyperactivity Disorder and Autism Spectrum Disorders: Current Status and Promising Directions.Current topics in behavioral neurosciences · 2022Article
- Mapping the genetic and environmental aetiology of autistic traits in Sweden and the United Kingdom.JCPP advances · 2021Article
- Pattern Unifies Autism.Frontiers in psychiatry · 2021Article
- ASD Phenotype-Genotype Associations in Concordant and Discordant Monozygotic and Dizygotic Twins Stratified by Severity of Autistic Traits.International journal of molecular sciences · 2019Article
- A Low Rank Model for Phenotype Imputation in Autism Spectrum Disorder.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2018Article
- Sensory perception in autism.Nature reviews. Neuroscience · 2017Review
- Association of Sex With Recurrence of Autism Spectrum Disorder Among Siblings.JAMA pediatrics · 2017Observational
- Developmental neurogenetics and multimodal neuroimaging of sex differences in autism.Brain imaging and behavior · 2017Review
- Serum Oxytocin Levels and an Oxytocin Receptor Gene Polymorphism (rs2254298) Indicate Social Deficits in Children and Adolescents with Autism Spectrum Disorders.Frontiers in neuroscience · 2017Article
- Rare Inherited and De Novo CNVs Reveal Complex Contributions to ASD Risk in Multiplex Families.American journal of human genetics · 2016Article
- Social (Pragmatic) Communication Disorder and Its Relation to the Autism Spectrum: Dilemmas Arising From the DSM-5 Classification.Journal of autism and developmental disorders · 2016Review
- The Genetic Overlap of Attention-Deficit/Hyperactivity Disorder and Autistic-like Traits: an Investigation of Individual Symptom Scales and Cognitive markers.Journal of abnormal child psychology · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Autistic traits-social impairment, communication impairment, and restricted and repetitive behaviors and interests-are heritable in the general population. Previous analyses have consistently reported limited genetic and environmental overlap between autistic trait domains in samples assessed in middle childhood. Here we extend this research to parent-report data for 12-year-olds. Data from 5,944 pairs in the Twins Early Development Study were analyzed to explore the domain-specific heritability and degree of shared genetic and environmental influences across different autistic traits in the general population and among individuals scoring in the top 5% of each domain. Sex differences in the etiological estimates were also tested in these analyses. Autistic traits were moderately to highly heritable (0.58-0.88) at age 12. Bivariate genetic correlations in the full sample (0.18-0.40) and the extremes (0.24-0.67), as well as even lower unique environmental correlations, all suggested considerable fractionation of genetic and environmental influences across autistic trait domains, in line with previous findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.