ReviewCurrent allergy and asthma reports2011
Reassessing the evidence hierarchy in asthma: evaluating comparative effectiveness.
Review in Current allergy and asthma reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- The Salford Lung Study protocol: a pragmatic, randomised phase III real-world effectiveness trial in asthma.BMC pulmonary medicine · 2015Trial
- The Salford Lung Study protocol: a pragmatic, randomised phase III real-world effectiveness trial in chronic obstructive pulmonary disease.Respiratory research · 2015Trial
- Efficacy, safety and tolerability of GSK2190915, a 5-lipoxygenase activating protein inhibitor, in adults and adolescents with persistent asthma: a randomised dose-ranging study.Respiratory research · 2013Trial
- Development of a Mobile App to Monitor the Effectiveness of a Hydrolyzed Cartilage Matrix Supplement on Joint Discomfort: Real-World Study.JMIR formative research · 2023Article
- Excimer laser ablation combined with drug-coated balloon versus drug-coated balloon in the treatment of de novo atherosclerotic lesions in lower extremities (ELABORATE): study protocol for a real-world clinical trial.BMC cardiovascular disorders · 2022Article
- Observational studies assessing the pharmacological treatment of obstructive lung disease: strengths, challenges and considerations for study design.ERJ open research · 2020Review
- Effect of combination of pre- and postoperative pulmonary rehabilitation on onset of postoperative pneumonia: a retrospective cohort study based on data from the diagnosis procedure combination database in Japan.International journal of clinical oncology · 2019Article
- Quality standards in respiratory real-life effectiveness research: the REal Life EVidence AssessmeNt Tool (RELEVANT): report from the Respiratory Effectiveness Group-European Academy of Allergy and Clinical Immunology Task Force.Clinical and translational allergy · 2019Article
- Real world data: an opportunity to supplement existing evidence for the use of long-established medicines in health care decision making.Journal of multidisciplinary healthcare · 2018Article
- The North-Western Italian experience with anti IL-5 therapy amd comparison with regulatory trials.The World Allergy Organization journal · 2018Article
- The frequency of, and adherence to, single maintenance and reliever therapy instructions in asthma: a descriptive analysis.NPJ primary care respiratory medicine · 2016Article
- Effectiveness of initiating extrafine-particle versus fine-particle inhaled corticosteroids as asthma therapy in the Netherlands.BMC pulmonary medicine · 2016Article
- Add-on LABA in a separate inhaler as asthma step-up therapyERJ open research · 2016Article
- Asthma.Nature reviews. Disease primers · 2015Review
- Effectiveness of Montelukast on asthma control in infants: methodology of a French claims data study.BMC pulmonary medicine · 2015Observational
- Real-world research and its importance in respiratory medicine.Breathe (Sheffield, England) · 2015Review
- Oral Calcidiol Is More Effective Than Cholecalciferol Supplementation to Reach Adequate 25(OH)D Levels in Patients with Autoimmune Diseases Chronically Treated with Low Doses of Glucocorticoids: A "Real-Life" Study.Journal of osteoporosis · 2015Article
- Impact of changes to reimbursement of fixed combinations of inhaled corticosteroids and long-acting β₂ -agonists in obstructive lung diseases: a population-based, observational study.International journal of clinical practice · 2014Observational
- Stratified approaches to the treatment of asthma.British journal of clinical pharmacology · 2013Review
- Inhaled corticosteroids used for the control of asthma in a "real-life" setting do not affect linear growth velocity in prepubertal children.Medical science monitor : international medical journal of experimental and clinical research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Classical randomized controlled trials are the gold standard in medical evidence because of their high internal validity. However, their necessarily strict design can limit their external validity and the ability to extrapolate these data to real world patients. Therefore, alternatively designed studies may play a complementary role in evaluating the comparative effectiveness of therapies in nonidealized patients in more naturalistic, real world settings. Observational studies have high external validity and can evaluate real world outcomes. Their strength lies in hypothesis generation and testing and in identifying areas in which further clinical trials may be required. Pragmatic trials are designed to maximize applicability of trial results to usual care settings by relying on clinically important outcomes and enrolling a wide range of participants. A combination of these approaches is preferable and necessary.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.