Trial reportDiabetologia2012
High cerebral insulin sensitivity is associated with loss of body fat during lifestyle intervention.
Trial report in Diabetologia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 63 citations in OpenAlex.
- Exercise restores brain insulin sensitivity in sedentary adults who are overweight and obese.JCI insight · 2022Trial
- Brain glucose uptake is associated with endogenous glucose production in obese patients before and after bariatric surgery and predicts metabolic outcome at follow-up.Diabetes, obesity & metabolism · 2019Trial
- Nomogram for Predicting Suboptimal Weight Loss at Three Years after Roux-en-Y Gastric Bypass Surgery in Chinese Patients with Obesity and Type 2 Diabetes.Obesity facts · 2025Article
- The insulin resistant brain: impact on whole-body metabolism and body fat distribution.Diabetologia · 2024Review
- Dorsal striatal response to taste is modified by obesity and insulin resistance.Obesity (Silver Spring, Md.) · 2023Article
- Decreased Weight Loss Following Bariatric Surgery in Patients with Type 2 Diabetes.Obesity surgery · 2023Article
- Obesity risk is associated with brain glucose uptake and insulin resistance.European journal of endocrinology · 2022Article
- Brain insulin signalling in metabolic homeostasis and disease.Nature reviews. Endocrinology · 2021Review
- Ectopic fat accumulation in human astrocytes impairs insulin action.Royal Society open science · 2020Article
- Brain free fatty acid uptake is elevated in morbid obesity, and is irreversible 6 months after bariatric surgery: A positron emission tomography study.Diabetes, obesity & metabolism · 2020Article
- Programming of central and peripheral insulin resistance by low birthweight and postnatal catch-up growth in male mice.Diabetologia · 2018Article
- Central Nervous Insulin Administration before Nocturnal Sleep Decreases Breakfast Intake in Healthy Young and Elderly Subjects.Frontiers in neuroscience · 2017Article
- Interaction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity.Diabetologia · 2016Article
- Novel phenotypes of prediabetes?Diabetologia · 2016Review
- Review
- Sustained Treatment with Insulin Detemir in Mice Alters Brain Activity and Locomotion.PloS one · 2016Article
- Impaired insulin action in the human brain: causes and metabolic consequences.Nature reviews. Endocrinology · 2015Review
- The brain response to peripheral insulin declines with age: a contribution of the blood-brain barrier?PloS one · 2015Article
- Maternal insulin sensitivity is associated with oral glucose-induced changes in fetal brain activity.Diabetologia · 2014Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisLoss of weight and body fat are major targets in lifestyle interventions to prevent diabetes. In the brain, insulin modulates eating behaviour and weight control, resulting in a negative energy balance. This study aimed to test whether cerebral insulin sensitivity facilitates reduction of body weight and body fat by lifestyle intervention in humans.
methodsThe study was performed as an additional arm of the TUebingen Lifestyle Intervention Program (TULIP). In 28 non-diabetic individuals (14 female/14 male; mean ± SE age 42 ± 2 years; mean ± SE BMI 29.9 ± 0.8 kg/m²), we measured cerebrocortical insulin sensitivity by using magnetoencephalography before lifestyle intervention. Total and visceral fat were measured by using MRI at baseline and after 9 months and 2 years of lifestyle intervention.
resultsInsulin-stimulated cerebrocortical theta activity at baseline correlated with a reduction in total adipose tissue (r = -0.59, p = 0.014) and visceral adipose tissue (r = -0.76, p = 0.001) after 9 months of lifestyle intervention, accompanied by a statistical trend for reduction in body weight change (r = -0.37, p = 0.069). Similar results were obtained after 2 years. CONCLUSIONS/
interpretationOur results suggest that high insulin sensitivity of the human brain facilitates loss of body weight and body fat during lifestyle intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.