ArticleNeuroradiology2012
Hypoactivation of the primary sensorimotor cortex in de novo Parkinson's disease : a motor fMRI study under controlled conditions.
Article in Neuroradiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Brain Motor Network Changes in Parkinson's Disease: Evidence from Meta-Analytic Modeling.Movement disorders : official journal of the Movement Disorder Society · 2021Pooled it
- Altered white matter microarchitecture in Parkinson's disease: a voxel-based meta-analysis of diffusion tensor imaging studies.Frontiers of medicine · 2021Pooled it
- Functional neuroimaging of motor control in Parkinson's disease: a meta-analysis.Human brain mapping · 2014Pooled it
- Trial
- Transcutaneous auricular vagus nerve stimulation improves cortical functional topological properties and intracortical facilitation in patients with Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Cortical activation and functional connectivity during locomotion tasks in Parkinson's disease with freezing of gait.Frontiers in aging neuroscience · 2023Article
- Altered Spontaneous Neural Activity and Functional Connectivity in Parkinson's Disease With Subthalamic Microlesion.Frontiers in neuroscience · 2021Article
- Cerebral blood flow and cerebrovascular reactivity correlate with severity of motor symptoms in Parkinson's disease.Therapeutic advances in neurological disorders · 2019Article
- Objectively measuring effects of electro-acupuncture in parkinsonian rhesus monkeys.Brain research · 2018Article
- Levodopa response differs in Parkinson's motor subtypes: A task-based effective connectivity study.The Journal of comparative neurology · 2017Article
- Primary motor cortex of the parkinsonian monkey: altered encoding of active movement.Brain : a journal of neurology · 2016Article
- Magnetic Resonance Techniques Applied to the Diagnosis and Treatment of Parkinson's Disease.Frontiers in neurology · 2015Review
- Complex deregulation and expression of cytokines and mediators of the immune response in Parkinson's disease brain is region dependent.Brain pathology (Zurich, Switzerland) · 2014Article
- MRI reveals brain abnormalities in drug-naive Parkinson's disease.Exercise and sport sciences reviews · 2014Review
- Novel magnetomechanical MR compatible vibrational device for producing kinesthetic illusion during fMRI.Medical physics · 2013Article
- Decreased parvalbumin mRNA expression in dorsolateral prefrontal cortex in Parkinson's disease.Brain research · 2013Article
- Motor matters: tackling heterogeneity of Parkinson's disease in functional MRI studies.PloS one · 2013Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionNuclear medicine studies in Parkinson's disease (PD) indicate that nigrostriatal damage causes a widespread cortical hypoactivity assumed to be due to reduced excitatory thalamic outflow. However, so far, functional MRI (fMRI) studies have provided controversial data about this "functional deafferentation" phenomenon. To further clarify this issue, we assessed, with fMRI, de novo drug-naive PD patients using a relatively complex motor task under strictly controlled conditions.
methodsNineteen de novo PD patients with right-predominant or bilateral symptoms and 13 age-matched healthy volunteers performed continuous writing of "8" figures with the right-dominant hand using a MR-compatible device that enables identification of incorrectly performed tasks and measures the size and the frequency of the "8"s. The data were analyzed with FSL software and correlated with the clinical severity rated according to the Hoehn and Yahr (HY) staging system.
resultsFifteen (89%) of 19 PD patients and 12 (92%) of 13 controls correctly executed the task. PD patients showed significant hypoactivation of the left primary sensorimotor cortex (SM1) and cerebellum and no hyperactive areas as compared to controls. However, activation in SM1 and supplementary motor area bilaterally, in left supramarginal, parietal inferior, parietal superior and frontal superior gyri as well as in right parietal superior and angular gyri paralleled increasing disease severity as assessed with the HY stage.
conclusionsIn line with the "deafferentation hypothesis", fMRI demonstrates hypoactivation of the SM1 in the early clinical stage of PD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.