Evidence map›Paper›PMID 21927634›Full record

ReviewCurrent opinion in virology2011

Cell entry of enveloped viruses.

Richard K Plemper

Abstract readReview
In one paragraph

Review in Current opinion in virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed.

  1. Membrane-Targeting Antivirals.International journal of molecular sciences · 2025
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Richard K PlemperDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA. rplempe@emory.edu

Funding

Identification and Pre-Clinical Evaluation of Measles Virus InhibitorsR01AI071002 · NIAID · GEORGIA STATE UNIVERSITY · PI PLEMPER, RICHARD K. · 2006 to 2022
$6.6M
Cryo-Electron and Biochemical Anaysis of Native Paramyxovirus Fusion ComplexesR01AI083402 · NIAID · GEORGIA STATE UNIVERSITY · PI PLEMPER, RICHARD K. · 2011 to 2015
$1.7M
Cryo-Electron and Biochemical Analysis of Native Paramyxovirus Fusion ComplexesR56AI083402 · NIAID · EMORY UNIVERSITY · PI PLEMPER, RICHARD K. · 2010 to 2010
$380k
NIAID NIH HHS AI071002NIAID NIH HHS AI083402NIAID NIH HHS R01 AI071002NIAID NIH HHS R01 AI083402NIAID NIH HHS R56 AI083402
6 · The paper itself

Abstract

Infection of cells by enveloped viruses requires merger of the viral envelope membrane with target cell membranes, resulting in the formation of fusion pores through which the viral genome is released. Since lipid membranes do not mix spontaneously, the fusion process is energy-dependent and mediated by viral envelope glycoprotein complexes. Based on their structural and mechanistic properties, three distinct classes of viral fusion proteins have been identified to date. Despite their diversity, basic principles of viral membrane fusion, simultaneous engagement of both donor and target membrane and refolding into hairpin-like structures, have emerged as universally conserved. This article provides an overview of the basic principles of viral membrane fusion common to all enveloped viruses and discusses the specific structural and functional features of the different fusion protein classes by example of the paramyxovirus, flavivirus and rhabdovirus families.

Indexed as

Virus InternalizationAnimalsHumansViral Envelope ProteinsVirus DiseasesVirusesVirus Physiological PhenomenaViral Envelope Proteins

Identifiers

PMID21927634
PMCPMC3171968

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.