ArticlePancreas2011
Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2rγnull Ins2Akita mice.
Abstract readLetter
In one paragraph
Article in Pancreas, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Dual role of neuroplastin in pancreatic β cells: Regulating insulin secretion and promoting islet inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Mouse models and human islet transplantation sites for intravital imaging.Frontiers in endocrinology · 2022Review
- Preclinical Models to Evaluate the Human Response to Autoantigen and Antigen-Specific Immunotherapy in Human Type 1 Diabetes.Frontiers in endocrinology · 2022Review
- The Potential of Albuminuria as a Biomarker of Diabetic Complications.Cardiovascular drugs and therapy · 2021Review
- Pronounced proliferation of non-beta cells in response to beta-cell mitogens in isolated human islets of Langerhans.Scientific reports · 2021Article
- Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Pancreatic Beta Cell Death: Novel Potential Mechanisms in Diabetes Therapy.Journal of diabetes research · 2018Review
- Islet biology, the CDKN2A/B locus and type 2 diabetes risk.Diabetologia · 2016Review
- Inhibition of DYRK1A Stimulates Human β-Cell Proliferation.Diabetes · 2016Article
- Stress-impaired transcription factor expression and insulin secretion in transplanted human islets.The Journal of clinical investigation · 2016Article
- Article
- Glucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin Receptor.Diabetes · 2016Article
- Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD-scid IL-2rg(null) RIP-DTR mice engrafted with human islets.Diabetes, metabolic syndrome and obesity : targets and therapy · 2015Article
- Human β-cell regeneration: progress, hurdles, and controversy.Current opinion in endocrinology, diabetes, and obesity · 2014Review
- Improved function and proliferation of adult human beta cells engrafted in diabetic immunodeficient NOD-scid IL2rγ(null) mice treated with alogliptin.Diabetes, metabolic syndrome and obesity : targets and therapy · 2013Article
- Advancing animal models of human type 1 diabetes by engraftment of functional human tissues in immunodeficient mice.Cold Spring Harbor perspectives in medicine · 2012Review
- Humanized mice for the study of type 1 and type 2 diabetes.Annals of the New York Academy of Sciences · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Philip Diiorio
Agata Jurczyk
Chaoxing Yang
Waldemar J Racki
Michael A Brehm
Mark A Atkinson
Alvin C Powers
Leonard D Shultz
Dale L Greiner
Rita Bortell
Funding
Coordinating Center for Beta Cell Biology ConsortiumU01DK072473 · NIDDK · VANDERBILT UNIVERSITY · PI MAGNUSON, MARK A · 2005 to 2014
$61.0MVanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3MTRANSGENIC MOUSE/ ES CELL SHARES RESOURCESP60DK020593 · NIDDK · VANDERBILT UNIVERSITY · PI MCGUINNESS, OWEN P · 1986 to 2011
$28.1MVirology and Technology CoreP01AI046629 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BREHM, MICHAEL ALLEN · 1999 to 2014
$19.1MPILOT AND FEASIBILITY PROGRAMP30DK032520 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CZECH, MICHAEL P · 1986 to 2010
$14.6MMolecular Mechanisms of Human and Murine Beta Cell Proliferation and RegenerationU01DK089572 · NIDDK · VANDERBILT UNIVERSITY · PI GREINER, DALE LESLIE, HARLAN, DAVID MARSHALL · 2010 to 2014
$8.4MMolecular Genetics and Mechanisms of ThrombocytopeniaR01HL077642 · NHLBI · JACKSON LABORATORY · PI SHULTZ, LEONARD D. · 2004 to 2007
$1.7MGLP-1 to Enhance Islet TransplantationR33DK066636 · NIDDK · VANDERBILT UNIVERSITY · PI POWERS, ALVIN C · 2005 to 2007
$1.5MVEGF and Islet VascularizationR01DK069603 · NIDDK · VANDERBILT UNIVERSITY · PI POWERS, ALVIN C · 2005 to 2010
$1.3MGLP-1 to Enhance Islet TransplantationR21DK066636 · NIDDK · VANDERBILT UNIVERSITY · PI POWERS, ALVIN CARTER · 2003 to 2004
$722kPdx-1 and Maf Proteins in Human IsletsR21DK068854 · NIDDK · VANDERBILT UNIVERSITY · PI POWERS, ALVIN CARTER · 2004 to 2005
$680kIslet alterations in type 2 diabetesI01BX000666 · VA · VETERANS HEALTH ADMINISTRATION · PI POWERS, ALVIN C · 2011 to 2025
–BLRD VA I01 BX000666NHLBI NIH HHS HL077642NHLBI NIH HHS R01 HL077642NIAID NIH HHS AI46629NIAID NIH HHS P01 AI046629NIDDK NIH HHS DK20593NIDDK NIH HHS DK32520NIDDK NIH HHS DK66636NIDDK NIH HHS DK68854NIDDK NIH HHS DK69603NIDDK NIH HHS DK72473NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK032520NIDDK NIH HHS P60 DK020593NIDDK NIH HHS R01 DK069603NIDDK NIH HHS R21 DK066636NIDDK NIH HHS R21 DK068854NIDDK NIH HHS R33 DK066636NIDDK NIH HHS U01 DK072473NIDDK NIH HHS U01 DK089572
Abstract
PubMed holds no abstract for this paper.
Indexed as
Cell ProliferationIslets of Langerhans TransplantationAnimalsBlood GlucoseDiabetes MellitusDisease Models, AnimalHomeodomain ProteinsHumansHyperglycemiaImmunocompromised HostInsulinInsulin-Secreting CellsInterleukin Receptor Common gamma SubunitMiceMice, Inbred NODMice, KnockoutBlood GlucoseHomeodomain ProteinsIl2rg protein, mouseIns2 protein, mouseInsulinInterleukin Receptor Common gamma SubunitRAG-1 protein
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.