ArticleThe Journal of clinical investigation2011
Circulating glucose levels modulate neural control of desire for high-calorie foods in humans.
Article in The Journal of clinical investigation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05121844 (Use of Continuous Glucose Monitoring in Non-Diabetic Population to Compliment Signos Mobile Health Platform), which is not on this map. Cited by 104 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Use of Continuous Glucose Monitoring in Non-Diabetic Population to Compliment Signos Mobile Health Platform: Comprehensive Weight Optimization Program and Customized Lifestyle Modifications
Who cites it
104 citing papers in PubMed, 1 synthesis or guideline pooled it, 214 citations in OpenAlex.
- Mapping brain activity of gut-brain signaling to appetite and satiety in healthy adults: A systematic review and functional neuroimaging meta-analysis.Neuroscience and biobehavioral reviews · 2022Pooled it
- Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights.Nature metabolism · 2025Trial
- Trial
- Obesity and Sex-Related Associations With Differential Effects of Sucralose vs Sucrose on Appetite and Reward Processing: A Randomized Crossover Trial.JAMA network open · 2021Trial
- Diets Varying in Carbohydrate Content Differentially Alter Brain Activity in Homeostatic and Reward Regions in Adults.The Journal of nutrition · 2021Trial
- Trial
- Dietary intake on days with and without hypoglycemia in youth with type 1 diabetes: The Flexible Lifestyle Empowering Change trial.Pediatric diabetes · 2020Trial
- Food Intake and Satiety Response after Medium-Chain Triglycerides Ingested as Solid or Liquid.Nutrients · 2019Trial
- Dysglycemia among youth with type 1 diabetes and suboptimal glycemic control in the Flexible Lifestyle Empowering Change trial.Pediatric diabetes · 2019Trial
- Humans with obesity have disordered brain responses to food images during physiological hyperglycemia.American journal of physiology. Endocrinology and metabolism · 2018Trial
- Hypoglycemia unawareness in type 1 diabetes suppresses brain responses to hypoglycemia.The Journal of clinical investigation · 2018Trial
- The Effects of Experimental Manipulation of Sleep Duration on Neural Response to Food Cues.Sleep · 2017Trial
- Obesity is associated with altered mid-insula functional connectivity to limbic regions underlying appetitive responses to foods.Journal of psychopharmacology (Oxford, England) · 2017Trial
- Link Between Increased Satiety Gut Hormones and Reduced Food Reward After Gastric Bypass Surgery for Obesity.The Journal of clinical endocrinology and metabolism · 2016Trial
- Ghrelin mimics fasting to enhance human hedonic, orbitofrontal cortex, and hippocampal responses to food.The American journal of clinical nutrition · 2014Trial
- Effects of dietary glycemic index on brain regions related to reward and craving in men.The American journal of clinical nutrition · 2013Trial
- Trial
- The role of neighborhood socioeconomic environment in the association between glycemic control and the developing brain.Brain imaging and behavior · 2026Article
- Feasibility of ConcurrentNMR in biomedicine · 2026Article
- The association between glucose dynamics and energy intake in young, healthy women.European journal of clinical nutrition · 2026Article
44 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Obesity is a worldwide epidemic resulting in part from the ubiquity of high-calorie foods and food images. Whether obese and nonobese individuals regulate their desire to consume high-calorie foods differently is not clear. We set out to investigate the hypothesis that circulating levels of glucose, the primary fuel source for the brain, influence brain regions that regulate the motivation to consume high-calorie foods. Using functional MRI (fMRI) combined with a stepped hyperinsulinemic euglycemic-hypoglycemic clamp and behavioral measures of interest in food, we have shown here that mild hypoglycemia preferentially activates limbic-striatal brain regions in response to food cues to produce a greater desire for high-calorie foods. In contrast, euglycemia preferentially activated the medial prefrontal cortex and resulted in less interest in food stimuli. Indeed, higher circulating glucose levels predicted greater medial prefrontal cortex activation, and this response was absent in obese subjects. These findings demonstrate that circulating glucose modulates neural stimulatory and inhibitory control over food motivation and suggest that this glucose-linked restraining influence is lost in obesity. Strategies that temper postprandial reductions in glucose levels might reduce the risk of overeating, particularly in environments inundated with visual cues of high-calorie foods.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.