ArticleAmerican journal of physiology. Heart and circulatory physiology2011
Mis-sizing of stent promotes intimal hyperplasia: impact of endothelial shear and intramural stress.
Article in American journal of physiology. Heart and circulatory physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 60 citations in OpenAlex.
- Intravascular imaging guidance for percutaneous coronary intervention and clinical outcomes: meta-analyses of randomized controlled trials.Cardiovascular intervention and therapeutics · 2026Review
- Arterial Occlusion Caused by Intimal Flap Elevation After Arteriosclerosis Obliterans Stent Implantation: A Case Report.Clinical case reports · 2026Article
- Endovascular repair using iliac branch devices for small-diameter abdominal aortic dissection aneurysm with proximal stenosis: a case report.Journal of medical case reports · 2026Article
- Postdilation Strategies Following Provisional Stenting of Left Main Coronary Bifurcations: Insights From Patient-Specific Computational Simulations.JACC. Advances · 2026Article
- Hemodynamic Significance of APEXCT Coronary Angiography Combined With Dynamic CT Myocardial Perfusion Imaging in Assessing Restenosis After Coronary Stenting.The Kaohsiung journal of medical sciences · 2026Article
- Parent Artery Disease-Related Stroke: What Is the Impact on Endovascular Treatment? A Narrative Review.Journal of clinical medicine · 2026Review
- Comparative analysis of stenting for carotid web and atherosclerotic disease.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Impact of Diameter Mismatch Between the Inflow Vein and Stent on Patency in Thrombotic Iliac Vein Lesions.Cardiovascular and interventional radiology · 2025Article
- Design and Simulation of the Biomechanics of Multi-Layered Composite Poly(Vinyl Alcohol) Coronary Artery Grafts.Frontiers in cardiovascular medicine · 2022Article
- The Role of Elevated Wall Shear Stress in Progression of Pulmonary Vein Stenosis: Evidence from Two Case Studies.Children (Basel, Switzerland) · 2021Article
- Electrical Conductance Device for Stent Sizing.Frontiers in physiology · 2019Article
- Patient-Specific Modeling of Stented Coronary Arteries Reconstructed from Optical Coherence Tomography: Towards a Widespread Clinical Use of Fluid Dynamics Analyses.Journal of cardiovascular translational research · 2018Review
- Hemodynamics and pathology of an enlarging abdominal aortic aneurysm model in rabbits.PloS one · 2018Article
- Biomechanical impact of provisional stenting and balloon dilatation on coronary bifurcation: clinical implications.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Microstructure-based biomechanics of coronary arteries in health and disease.Journal of biomechanics · 2016Review
- Impact of bifurcation dual stenting on endothelial shear stress.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Temporal correlation between wall shear stress and in-stent stenosis after Wingspan stent in swine model.AJNR. American journal of neuroradiology · 2014Article
- Structural analysis for Wingspan stent in a perforator model.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2013Article
- Impact of stent mis-sizing and mis-positioning on coronary fluid wall shear and intramural stress.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Which diameter and angle rule provides optimal flow patterns in a coronary bifurcation?Journal of biomechanics · 2012Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Stent can cause flow disturbances on the endothelium and compliance mismatch and increased stress on the vessel wall. These effects can cause low wall shear stress (WSS), high wall shear stress gradient (WSSG), oscillatory shear index (OSI), and circumferential wall stress (CWS), which may promote neointimal hyperplasia (IH). The hypothesis is that stent-induced abnormal fluid and solid mechanics contribute to IH. To vary the range of WSS, WSSG, OSI, and CWS, we intentionally mismatched the size of stents to that of the vessel lumen. Stents were implanted in coronary arteries of 10 swine. Intravascular ultrasound (IVUS) was used to size the coronary arteries and stents. After 4 wk of stent implantation, IVUS was performed again to determine the extent of IH. In conjunction, computational models of actual stents, the artery, and non-Newtonian blood were created in a computer simulation to yield the distribution of WSS, WSSG, OSI, and CWS in the stented vessel wall. An inverse relation (R(2) = 0.59, P < 0.005) between WSS and IH was found based on a linear regression analysis. Linear relations between WSSG, OSI, and IH were observed (R(2) = 0.48 and 0.50, respectively, P < 0.005). A linear relation (R(2) = 0.58, P < 0.005) between CWS and IH was also found. More statistically significant linear relations between the ratio of CWS to WSS (CWS/WSS), the products CWS × WSSG and CWS × OSI, and IH were observed (R(2) = 0.67, 0.54, and 0.56, respectively, P < 0.005), suggesting that both fluid and solid mechanics influence the extent of IH. Stents create endothelial flow disturbances and intramural wall stress concentrations, which correlate with the extent of IH formation, and these effects were exaggerated with mismatch of stent/vessel size. These findings reveal the importance of reliable vessel and stent sizing to improve the mechanics on the vessel wall and minimize IH.
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