ArticleGenetics2011
Regulation of manganese antioxidants by nutrient sensing pathways in Saccharomyces cerevisiae.
Article in Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- Sod1 integrates oxygen availability to redox regulate NADPH production and the thiol redoxome.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Cu/Zn Superoxide Dismutase (Sod1) regulates the canonical Wnt signaling pathway.Biochemical and biophysical research communications · 2021Article
- Harnessing biocompatible chemistry for developing improved and novel microbial cell factories.Microbial biotechnology · 2020Review
- Review
- Extra-mitochondrial Cu/Zn superoxide dismutase (Sod1) is dispensable for protection against oxidative stress but mediates peroxide signaling in Saccharomyces cerevisiae.Redox biology · 2019Article
- Across the tree of life, radiation resistance is governed by antioxidant MnProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Conserved electron donor complex Dre2-Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesis.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Manganese complexes: diverse metabolic routes to oxidative stress resistance in prokaryotes and yeast.Antioxidants & redox signaling · 2013Review
- Effects of intracellular Mn on the radiation resistance of the halophilic archaeon Halobacterium salinarum.Extremophiles : life under extreme conditions · 2013Article
- A manganese-rich environment supports superoxide dismutase activity in a Lyme disease pathogen, Borrelia burgdorferi.The Journal of biological chemistry · 2013Article
- Superoxide triggers an acid burst in Saccharomyces cerevisiae to condition the environment of glucose-starved cells.The Journal of biological chemistry · 2013Article
- Article
- Manganese acquisition and homeostasis at the host-pathogen interface.Frontiers in cellular and infection microbiology · 2013Review
- Battles with iron: manganese in oxidative stress protection.The Journal of biological chemistry · 2012Review
- Oxidative stress and programmed cell death in yeast.Frontiers in oncology · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In aerobic organisms, protection from oxidative damage involves the combined action of enzymatic and nonproteinaceous cellular factors that collectively remove harmful reactive oxygen species. One class of nonproteinaceous antioxidants includes small molecule complexes of manganese (Mn) that can scavenge superoxide anion radicals and provide a backup for superoxide dismutase enzymes. Such Mn antioxidants have been identified in diverse organisms; however, nothing regarding their physiology in the context of cellular adaptation to stress was known. Using a molecular genetic approach in Bakers' yeast, Saccharomyces cerevisiae, we report that the Mn antioxidants can fall under control of the same pathways used for nutrient sensing and stress responses. Specifically, a serine/threonine PAS-kinase, Rim15p, that is known to integrate phosphate, nitrogen, and carbon sensing, can also control Mn antioxidant activity in yeast. Rim15p is negatively regulated by the phosphate-sensing kinase complex Pho80p/Pho85p and by the nitrogen-sensing Akt/S6 kinase homolog, Sch9p. We observed that loss of either of these upstream kinase sensors dramatically inhibited the potency of Mn as an antioxidant. Downstream of Rim15p are transcription factors Gis1p and the redundant Msn2/Msn4p pair that typically respond to nutrient and stress signals. Both transcription factors were found to modulate the potency of the Mn antioxidant but in opposing fashions: loss of Gis1p was seen to enhance Mn antioxidant activity whereas loss of Msn2/4p greatly suppressed it. Our observed roles for nutrient and stress response kinases and transcription factors in regulating the Mn antioxidant underscore its physiological importance in aerobic fitness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.