ArticleDiabetes2011
High-resolution magnetic resonance imaging quantitatively detects individual pancreatic islets.
Article in Diabetes, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Diabetology and Nanotechnology: A Compelling Combination.Recent patents on nanotechnology · 2025Review
- Bibliometric analysis of research on the utilization of nanotechnology in diabetes mellitus and its complications.Nanomedicine (London, England) · 2024Article
- The anterior chamber of the eye technology and its anatomical, optical, and immunological bases.Physiological reviews · 2024Review
- Pancreatic beta cell autophagy is impaired in type 1 diabetes.Diabetologia · 2021Article
- Imaging β-Cell Function Using a Zinc-Responsive MRI Contrast Agent May Identify First Responder Islets.Frontiers in endocrinology · 2021Article
- Scientific Advances in Diabetes: The Impact of the Innovative Medicines Initiative.Frontiers in medicine · 2021Review
- PET/MRI enables simultaneousTheranostics · 2020Article
- The eye as a novel imaging site in diabetes research.Pharmacology & therapeutics · 2019Review
- Molecular imaging of β-cells: diabetes and beyond.Advanced drug delivery reviews · 2019Review
- Collective Sensing of β-Cells Generates the Metabolic Code.Frontiers in physiology · 2018Article
- Radiomanganese PET Detects Changes in Functional β-Cell Mass in Mouse Models of Diabetes.Diabetes · 2017Article
- Mapping of pain circuitry in early post-natal development using manganese-enhanced MRI in rats.Neuroscience · 2017Article
- Targets and probes for non-invasive imaging of β-cells.European journal of nuclear medicine and molecular imaging · 2017Review
- Nanodiamond-Gadolinium(III) Aggregates for Tracking Cancer Growth In Vivo at High Field.Nano letters · 2016Article
- Distribution of pancreatic B cell imaging agent (99m)Tc-DTPA-NGN2 in the body and animal experimental research on pancreatic B cell functional imaging.American journal of translational research · 2016Article
- Light scattering as an intrinsic indicator for pancreatic islet cell mass and secretion.Scientific reports · 2015Article
- Targeting GLP-1 receptors for repeated magnetic resonance imaging differentiates graded losses of pancreatic beta cells in mice.Diabetologia · 2015Article
- Managing diabetes with nanomedicine: challenges and opportunities.Nature reviews. Drug discovery · 2015Review
- Reporter islets in the eye reveal the plasticity of the endocrine pancreas.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Empirical mathematical model for dynamic manganese-enhanced MRI of the murine pancreas for assessment of β-cell function.Magnetic resonance imaging · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe studied whether manganese-enhanced high-field magnetic resonance (MR) imaging (MEHFMRI) could quantitatively detect individual islets in situ and in vivo and evaluate changes in a model of experimental diabetes. RESEARCH DESIGN AND
methodsWhole pancreata from untreated (n = 3), MnCl(2) and glucose-injected mice (n = 6), and mice injected with either streptozotocin (STZ; n = 4) or citrate buffer (n = 4) were imaged ex vivo for unambiguous evaluation of islets. Exteriorized pancreata of MnCl(2) and glucose-injected mice (n = 6) were imaged in vivo to directly visualize the gland and minimize movements. In all cases, MR images were acquired in a 14.1 Tesla scanner and correlated with the corresponding (immuno)histological sections.
resultsIn ex vivo experiments, MEHFMRI distinguished different pancreatic tissues and evaluated the relative abundance of islets in the pancreata of normoglycemic mice. MEHFMRI also detected a significant decrease in the numerical and volume density of islets in STZ-injected mice. However, in the latter measurements the loss of β-cells was undervalued under the conditions tested. The experiments on the externalized pancreata confirmed that MEHFMRI could visualize native individual islets in living, anesthetized mice.
conclusionsData show that MEHFMRI quantitatively visualizes individual islets in the intact mouse pancreas, both ex vivo and in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.