ArticleJournal of bacteriology2011
CodY-mediated regulation of guanosine uptake in Bacillus subtilis.
Article in Journal of bacteriology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence.MicrobiologyOpen · 2026Review
- Sugar supplementation enhances biofilm formation and extracellular polysaccharides production inFrontiers in microbiology · 2026Article
- Tale of Twin Bifunctional Second Messenger (p)ppGpp Synthetases and Their Function in Mycobacteria.ACS omega · 2023Review
- Guanine Limitation Results in CodY-Dependent and -Independent Alteration of Staphylococcus aureus Physiology and Gene Expression.Journal of bacteriology · 2018Article
- An in vivo high-throughput screening for riboswitch ligands using a reverse reporter gene system.Scientific reports · 2017Article
- Gene expression control byRNA (New York, N.Y.) · 2017Article
- A Tandem Liquid Chromatography-Mass Spectrometry-based Approach for Metabolite Analysis of Staphylococcus aureus.Journal of visualized experiments : JoVE · 2017Article
- Unknown unknowns: essential genes in quest for function.Microbial biotechnology · 2016Review
- Interplay of CodY and ScoC in the Regulation of Major Extracellular Protease Genes of Bacillus subtilis.Journal of bacteriology · 2016Article
- Intermediate Levels of Bacillus subtilis CodY Activity Are Required for Derepression of the Branched-Chain Amino Acid Permease, BraB.PLoS genetics · 2015Article
- Interactive regulation by the Bacillus subtilis global regulators CodY and ScoC.Molecular microbiology · 2015Article
- CodY regulates expression of the Bacillus subtilis extracellular proteases Vpr and Mpr.Journal of bacteriology · 2015Article
- Lowering GTP level increases survival of amino acid starvation but slows growth rate for Bacillus subtilis cells lacking (p)ppGpp.Journal of bacteriology · 2014Article
- Direct regulation of GTP homeostasis by (p)ppGpp: a critical component of viability and stress resistance.Molecular cell · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
CodY is a global transcriptional regulator known to control expression of more than 100 genes and operons in Bacillus subtilis. Some of the most strongly repressed targets of CodY, the nupNOPQ (formerly, yufNOPQ) genes, were found to encode a guanosine transporter. Using DNase I footprinting experiments, we identified two high-affinity CodY-binding sites in the regulatory region of the nupN gene. The two sites are located 50 bp upstream and 163 bp downstream of the transcription start site. The downstream site was responsible for 6- to 8-fold nupN repression in the absence of the upstream site. When the upstream site was intact, however, only a minor contribution of the downstream site to nupN regulation could be detected under the conditions tested. Both sites contained 15-bp CodY-binding motifs with two mismatches each with respect to the consensus sequence, AATTTTCWGTTTTAA. However, the experimentally determined binding sites included additional sequences flanking the 15-bp CodY-binding motifs. An additional version of the 15-bp CodY-binding motif, with 5 mismatches with respect to the consensus but essential for efficient regulation by CodY, was found within the upstream site. The presence of multiple 15-bp motifs may be a common feature of CodY-binding sites.
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Registered trials
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