ReviewJournal of hand therapy : official journal of the American Society of Hand Therapists
Tendon biomechanics and mechanobiology--a minireview of basic concepts and recent advancements.
Review in Journal of hand therapy : official journal of the American Society of Hand Therapists. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
131 citing papers in PubMed, 1 synthesis or guideline pooled it, 328 citations in OpenAlex.
- Molecular and Biologic Effects of Platelet-Rich Plasma (PRP) in Ligament and Tendon Healing and Regeneration: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Clinical efficacy of the topical application of tranexamic acid in tendon release in the hand: A randomized controlled trial.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2024Trial
- Photobiomodulation and eccentric exercise for Achilles tendinopathy: a randomized controlled trial.Lasers in medical science · 2016Trial
- Postnatal Piezo1 deletion alters collagen fibril architecture in mouse Achilles tendon.Matrix biology plus · 2026Article
- Review
- Development of collagenous filaments with tuneable mechanical properties using a 3D bioprinter and molecular crowding.Biofabrication · 2026Article
- Collagen III Deficiency Following Injury in Female Murine Tendons Alters Matrix Composition, Structure, Organization and Function.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Analysis of Multi-Component Echo Decay in Achilles Tendon by NMR Spectroscopy.NMR in biomedicine · 2026Article
- Tendon-Targeted Knockout of Collagen XII Disrupts Murine Achilles Tendon Structure, Function, and Gene Expression at Later Stages of Postnatal Development.Annals of biomedical engineering · 2026Article
- Structure of tendon causes highly optical anisotropic properties and transport.Journal of biomedical optics · 2026Article
- Bioprinting of Microtissues Within Mechanically Tunable Support Baths to Engineer Anisotropic Musculoskeletal Tissues.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Tendon healing in the era of regenerative medicine: literature review.Annals of translational medicine · 2026Review
- A sport-medicine-education collaborative intervention framework for patellar tendinopathy: theoretical foundation and implementation pathway.BMC sports science, medicine & rehabilitation · 2026Article
- Tendon, Ligament, and Muscle Injury, Osteotendinous, Myotendinous, and Muscle-to-Bone Junction Therapy Perspectives with Growth Factors and Stable Gastric Pentadecapeptide BPC 157-A Review.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Impact of COVID-19 on patellar tendon properties over the first year after infection.Scientific reports · 2026Article
- VALIDATION OF AN OPTICAL METHOD FOR MEASURING THE GAP BETWEEN SUTURED TENDON STUMPS.Acta ortopedica brasileira · 2026Article
- Integrated strategies in meniscus tissue engineering: from biomaterials to stem cell-driven regeneration.Frontiers in bioengineering and biotechnology · 2026Review
- Advances in Achilles Tendon Tissue Engineering: Integrating Cells, Scaffolds, and Mechanical Loading for Functional Regeneration.Bioengineering (Basel, Switzerland) · 2025Review
- Intratendinous Normal Saline Injection of Quadriceps and Patellar Tendon Allografts Does Not Reduce Mechanical Strength at Time Zero.Arthroscopy, sports medicine, and rehabilitation · 2025Article
- Open Challenges and Opportunities in Piezoelectricity for Tissue Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
71 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Due to their unique hierarchical structure and composition, tendons possess characteristic biomechanical properties, including high mechanical strength and viscoelasticity, which enable them to carry and transmit mechanical loads (muscular forces) effectively. Tendons are also mechanoresponsive by adaptively changing their structure and function in response to altered mechanical loading conditions. In general, mechanical loading at physiological levels is beneficial to tendons, but excessive loading or disuse of tendons is detrimental. This mechanoadaptability is due to the cells present in tendons. Tendon fibroblasts (tenocytes) are the dominant tendon cells responsible for tendon homeostasis and repair. Tendon stem cells (TSCs), which were recently discovered, also play a vital role in tendon maintenance and repair by virtue of their ability to self-renew and differentiate into tenocytes. TSCs may also be responsible for chronic tendon injury, or tendinopathy, by undergoing aberrant differentiation into nontenocytes in response to excessive mechanical loading. Thus, it is necessary to devise optimal rehabilitation protocols to enhance tendon healing while reducing scar tissue formation and tendon adhesions. Moreover, along with scaffolds that can mimic tendon matrix environments and platelet-rich plasma, which serves as a source of growth factors, TSCs may be the optimal cell type for enhancing repair of injured tendons.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.