ArticleActa biomaterialia2012
Regulation of endothelial cell activation and angiogenesis by injectable peptide nanofibers.
Article in Acta biomaterialia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 64 citations in OpenAlex.
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- IL-10 promotes endothelial progenitor cell infiltration and wound healing via STAT3.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Histomorphometry of Ossification in Functionalised Ceramics with Tripeptide Arg-Gly-Asp (RGD): An In Vivo Study.Life (Basel, Switzerland) · 2022Article
- Biomedical applications of electrospun nanofibers in the management of diabetic wounds.Drug delivery and translational research · 2022Review
- Combining Biocompatible and Biodegradable Scaffolds and Cold Atmospheric Plasma for Chronic Wound Regeneration.International journal of molecular sciences · 2021Review
- Effect of Integrin Binding Peptide on Vascularization of Scaffold-Free Microtissue Spheroids.Tissue engineering and regenerative medicine · 2020Article
- Nanotechnology in the Future Treatment of Diabetic Wounds.The review of diabetic studies : RDS · 2020Review
- Enzyme Entrapment in Amphiphilic Myristyl-Phenylalanine Hydrogels.Molecules (Basel, Switzerland) · 2019Article
- Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection.Science (New York, N.Y.) · 2019Article
- Self-Assembling Peptide Gels for 3D Prostate Cancer Spheroid Culture.Macromolecular bioscience · 2019Article
- A Supramolecular Vaccine Platform Based on α-Helical Peptide Nanofibers.ACS biomaterials science & engineering · 2017Article
- In Vitro Bioactivity Study of RGD-Coated Titanium Alloy Prothesis for Revision Total Hip Arthroplasty.BioMed research international · 2016Article
- Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials.Chemical reviews · 2015Review
- Nanofiber Microenvironment Effectively Restores Angiogenic Potential of Diabetic Endothelial Cells.Advances in wound care · 2014Article
- KNDC1 knockdown protects human umbilical vein endothelial cells from senescence.Molecular medicine reports · 2014Article
- Angiogenic microenvironment augments impaired endothelial responses under diabetic conditions.American journal of physiology. Cell physiology · 2014Article
- The Role of Endothelial Progenitor Cells in Postnatal Vasculogenesis: Implications for Therapeutic Neovascularization and Wound Healing.Advances in wound care · 2013Review
- Regulation of endothelial MAPK/ERK signalling and capillary morphogenesis by low-amplitude electric field.Journal of the Royal Society, Interface · 2013Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
RAD16-II peptide nanofibers are promising for vascular tissue engineering and were shown to enhance angiogenesis in vitro and in vivo, although the mechanism remains unknown. We hypothesized that the pro-angiogenic effect of RAD16-II results from low-affinity integrin-dependent interactions of microvascular endothelial cells (MVECs) with RAD motifs. Mouse MVECs were cultured on RAD16-II with or without integrin and MAPK/ERK pathway inhibitors, and angiogenic responses were quantified. The results were validated in vivo using a mouse diabetic wound healing model with impaired neovascularization. RAD16-II stimulated spontaneous capillary morphogenesis, and increased β(3) integrin phosphorylation and VEGF expression in MVECs. These responses were abrogated in the presence of β(3) and MAPK/ERK pathway inhibitors or on the control peptide without RAD motifs. Wide-spectrum integrin inhibitor echistatin completely abolished RAD16-II-mediated capillary morphogenesis in vitro and neovascularization and VEGF expression in the wound in vivo. The addition of the RGD motif to RAD16-II did not change nanofiber architecture or mechanical properties, but resulted in significant decrease in capillary morphogenesis. Overall, these results suggest that low-affinity non-specific interactions between cells and RAD motifs can trigger angiogenic responses via phosphorylation of β(3) integrin and MAPK/ERK pathway, indicating that low-affinity sequences can be used to functionalize biocompatible materials for the regulation of cell migration and angiogenesis, thus expanding the current pool of available motifs that can be used for such functionalization. Incorporation of RAD or similar motifs into protein engineered or hybrid peptide scaffolds may represent a novel strategy for vascular tissue engineering and will further enhance design opportunities for new scaffold materials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.