Essential role of PIKE GTPases in neuronal protection against excitotoxic insults.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

10 citing papers in PubMed.

1. Netrin-1: Dual Roles in Neuroinflammation and Neurodegenerative Disease Dynamics.International journal of inflammation · 2025
   Review
2. Interactions Between the Canonical WNT/Beta-Catenin Pathway and PPAR Gamma on Neuroinflammation, Demyelination, and Remyelination in Multiple Sclerosis.Cellular and molecular neurobiology · 2018
   Review
3. α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation.Proceedings of the National Academy of Sciences of the United States of America · 2017
   Article
4. Intracellular signaling pathway regulation of myelination and remyelination in the CNS.Experimental neurology · 2016
   Review
5. Increased expression of the PI3K enhancer PIKE mediates deficits in synaptic plasticity and behavior in fragile X syndrome.Cell reports · 2015
   Article
6. PIKE is essential for oligodendroglia development and CNS myelination.Proceedings of the National Academy of Sciences of the United States of America · 2014
   Article
7. The PIKE homolog Centaurin gamma regulates developmental timing in Drosophila.PloS one · 2014
   Article
8. The roles of PIKE in tumorigenesis.Acta pharmacologica Sinica · 2013
   Review
9. Phosphoinositide 3-kinase enhancer (PIKE) in the brain: is it simply a phosphoinositide 3-kinase/Akt enhancer?Reviews in the neurosciences · 2012
   Review
10. What we have learnt about PIKE from the knockout mice.International journal of biochemistry and molecular biology · 2011
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

7 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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