Evidence map›Paper›PMID 21925377›Full record

ReviewMolecular cell2011

Regulation by small RNAs in bacteria: expanding frontiers.

Gisela Storz, Jörg Vogel, Karen M Wassarman

Open access · bronzeAbstract readReview
In one paragraph

Review in Molecular cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 688 papers.

0numbers the graph read from it
0cells of the map it votes in
688citing papers in PubMed
53.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

688 citing papers in PubMed, 1,178 citations in OpenAlex.

  1. Article
  2. Inducible Protein Knockdown via Engineered Small RNAs in Chlamydia.Methods in molecular biology (Clifton, N.J.) · 2027
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Small non-coding RNAMicrobiology spectrum · 2026
    Article
  10. Journal of molecular biology · 2026
    Article
  11. Article
  12. Distribution of prophage-encoded Pas sRNAs across pathogenicbioRxiv : the preprint server for biology · 2026
    Article
  13. Article
  14. TheInfection and immunity · 2026
    Article
  15. Review
  16. Article
  17. Very high CONAR genomics and bioinformatics · 2026
    Article
  18. Article
  19. Article
  20. iScience · 2026
    Article

628 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Gisela StorzCell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 18 Library Drive, Bethesda, MD 20892-5430, USA. storz@helix.nih.gov
Jörg Vogel
Karen M Wassarman
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USUniversity of Wisconsin–Madison · USUniversity of Würzburg · DE

Funding

Small Regulatory RNAsZIAHD001608 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI STORZ, GISELA · 2009 to 2025
$16.9M
Regulation Of Transcription by 6S RNAR01GM067955 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI WASSARMAN, KAREN M · 2003 to 2018
$3.6M
ASM Conference on Regulating with RNA in BacteriaR13GM096742 · NIGMS · AMERICAN SOCIETY FOR MICROBIOLOGY · PI WASSARMAN, KAREN M · 2011 to 2011
$10k
Intramural NIH HHS ZIA HD001608NIGMS NIH HHS R01 GM067955NIGMS NIH HHS R13 GM096742
6 · The paper itself

Abstract

Research on the discovery and characterization of small, regulatory RNAs in bacteria has exploded in recent years. These sRNAs act by base pairing with target mRNAs with which they share limited or extended complementarity, or by modulating protein activity, in some cases by mimicking other nucleic acids. Mechanistic insights into how sRNAs bind mRNAs and proteins, how they compete with each other, and how they interface with ribonucleases are active areas of discovery. Current work also has begun to illuminate how sRNAs modulate expression of distinct regulons and key transcription factors, thus integrating sRNA activity into extensive regulatory networks. In addition, the application of RNA deep sequencing has led to reports of hundreds of additional sRNA candidates in a wide swath of bacterial species. Most importantly, recent studies have served to clarify the abundance of remaining questions about how, when, and why sRNA-mediated regulation is of such importance to bacterial lifestyles.

Indexed as

Gene Expression RegulationBacteriaBase PairingModels, GeneticRNA, BacterialRNA-Binding ProteinsRNA, MessengerRNA, Small UntranslatedRNA, BacterialRNA-Binding ProteinsRNA, MessengerRNA, Small Untranslated

Identifiers

PMID21925377
PMCPMC3176440
OpenAlexW2046374424

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.