ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2011
Clinical variables identify seronegative HCV co-infection in HIV-infected individuals.
Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Diagnostic challenges from concurrent seronegative HCV and HIV antibody seroreversion in a person living with HIV: A case report.Infectious diseases & immunity · 2026Article
- Hepatitis C Virus Infection among HIV-Infected Patients Attending Dessie Referral Hospital, Northeastern Ethiopia.International journal of microbiology · 2021Article
- The First Case Report of Acute Symptomatic HEV Genotype 4 Infection in an HIV-positive Patient in Japan.Internal medicine (Tokyo, Japan) · 2020Article
- Neurocognitive impairment is worse in HIV/HCV-coinfected individuals with liver dysfunction.Journal of neurovirology · 2019Article
- Development and validation of the HCV-MOSAIC risk score to assist testing for acute hepatitis C virus (HCV) infection in HIV-infected men who have sex with men (MSM).Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2017Article
- Cancer prevention in HIV-infected populations.Seminars in oncology · 2016Review
- How I treat classical Hodgkin lymphoma in patients infected with human immunodeficiency virus.Blood · 2015Review
- Mechanisms of HIV-1 Tat neurotoxicity via CDK5 translocation and hyper-activation: role in HIV-associated neurocognitive disorders.Current HIV research · 2015Review
- Seronegative hepatitis C virus infection in a child infected via mother-to-child transmission.Journal of clinical microbiology · 2012Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundA substantial number of people living with HIV (PLWH) are co-infected with Hepatitis C Virus (HCV) but have a negative screening HCV antibody test (seronegative HCV infection, or SN-HCV).
objectiveTo identify a concise set of clinical variables that could be used to improve case finding for SN-HCV co-infection among PLWH. STUDY
designTwo hundred HIV-infected participants of the CHARTER study were selected based on 7 clinical variables associated with HCV infection but were HCV seronegative. Data were analyzed using Fisher's exact tests, receiver-operating characteristic (ROC) curves, and logistic regression.
resultsTwenty-six (13%) participants had detectable HCV RNA. SN-HCV was associated with a history of IDU, elevated ALT and AST, low platelets, black ethnicity, and undetectable HIV RNA in plasma. Each of these clinical variables, except for abnormal AST, remained independently associated with SN-HCV in a multivariate logistic regression analysis. A composite risk score correctly identified SN-HCV with sensitivity up to 85% and specificity up to 88%.
conclusionsIn a substantial minority of PLWH, seronegative HCV viremia can be predicted by a small number of clinical variables. These findings, after validation in an unselected cohort, could help focus screening in those at highest risk.
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