ArticleParkinsonism & related disorders2012
Unilateral subthalamic nucleus deep brain stimulation improves sleep quality in Parkinson's disease.
Article in Parkinsonism & related disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 66 citations in OpenAlex.
- Skin-attached bioadhesive patch enabling ultrasound deep brain stimulation and real-time electrophysiological monitoring for REM sleep enhancement.Nature communications · 2026Trial
- Sleep macro-architecture in patients with Parkinson's disease does not change during the first night of neurostimulation in a pilot study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Trial
- The effect of unilateral subthalamic nucleus deep brain stimulation on depression in Parkinson's disease.Brain stimulationTrial
- Sleep circuit modulation: from animal models to human translation.Brain : a journal of neurology · 2026Review
- Subthalamic CaMKIIα-expressing neurons facilitate recovery from propofol anesthesia via the STN-ventral pallidum pathway.Cell biology and toxicology · 2026Article
- Globus pallidus externus drives increase in network-wide alpha power with propofol-induced loss-of-consciousness in humans.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- The effects of deep brain stimulation on sleep: a systematic review and meta-analysis.Sleep advances : a journal of the Sleep Research Society · 2024Review
- Impaired night-time mobility in patients with Parkinson's disease: a systematic review.Frontiers in aging neuroscience · 2023Review
- The efficacy and safety of asleep and awake subthalamic deep brain stimulation for Parkinson's disease patients: A 1-year follow-up.Frontiers in aging neuroscience · 2023Article
- Parkinson's Disease Related Depression and Anxiety: A 22-Year Bibliometric Analysis (2000-2022).Neuropsychiatric disease and treatment · 2023Review
- Effects of deep brain stimulation on quantitative sleep electroencephalogram during non-rapid eye movement in Parkinson's disease.Frontiers in human neuroscience · 2023Article
- Review
- Deep brain stimulation in the globus pallidus alleviates motor activity defects and abnormal electrical activities of the parafascicular nucleus in parkinsonian rats.Frontiers in aging neuroscience · 2022Article
- Lateralized effects of deep brain stimulation in Parkinson's disease: evidence and controversies.NPJ Parkinson's disease · 2021Review
- Insomnia in neurological diseases.Neurological research and practice · 2021Article
- Effects of Deep Brain Stimulation on Sleep-Wake Disturbances in Patients with Parkinson's Disease: A Narrative Review.Current neuropharmacology · 2021Review
- Sleep disruption is not observed with brain-responsive neurostimulation for epilepsy.Epilepsia open · 2020Article
- The Impact of Deep Brain Stimulation on Sleep in Parkinson's Disease: An update.Journal of Parkinson's disease · 2020Review
- Brain MRI morphometric analysis in Parkinson's disease patients with sleep disturbances.BMC neurology · 2018Article
- Disturbances of Sleep and Alertness in Parkinson's Disease.Current neurology and neuroscience reports · 2018Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSleep disturbances are common in Parkinson's disease (PD). Bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) is superior to best medical therapy in the treatment of motor symptoms in advanced PD, and observational studies suggest that bilateral STN DBS improves sleep in these patients as well. Unilateral STN DBS also improves motor function in PD, but its effects on sleep have not been extensively investigated.
methodsWe report the effects of unilateral STN DBS on subjective sleep quality as measured by the Pittsburgh Sleep Quality Index (PSQI) in 53 consecutive PD patients. These subjects completed the PSQI prior to surgery and at 3 and 6 months post-operatively. The primary outcome measure was the change in the global PSQI at 6 months post-operatively versus the pre-operative baseline, measured with repeated measures analysis of variance (ANOVA).
resultsPatients with PD who underwent unilateral STN DBS had a significant improvement in PSQI at 6 months post-operatively (baseline 9.30 ± 0.56 (mean ± SEM), 6 months: 7.93 ± 0.56, p = 0.013). Supplemental analyses showed that subjects selected for STN DBS placed on the right had worse baseline subjective sleep quality and more improvement in PSQI at 6 months compared to patients who received left STN DBS.
conclusionThis prospective case series study provides evidence that unilateral STN DBS improves subjective sleep quality in patients with PD at up to 6 months post-operatively as measured by the PSQI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.