ArticleThe American journal of pathology2011
Proangiogenic Tie2(+) macrophages infiltrate human and murine endometriotic lesions and dictate their growth in a mouse model of the disease.
Article in The American journal of pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.
- Food groups and nutrients consumption and risk of endometriosis: a systematic review and meta-analysis of observational studies.Nutrition journal · 2022Pooled it
- Review
- VHL Suppresses Angiogenesis Through HIF-1a-Mediated Ang/Tie2/AMPK/VEGF Signaling Pathway in Tie-2 Expressed Macrophages (TEMs).Biochemical genetics · 2026Article
- Parabacteroides goldsteinii and its metabolite 7-KLCA attenuate endometriosis via TGR5 to reprogram macrophages by modulating the PPARγ/GPR132 axis.NPJ biofilms and microbiomes · 2026Article
- Repeatedly occurring retrograde menstruation intensifies central sensitization driven by neuroinflammation in endometriosis models.The Journal of clinical investigation · 2026Article
- Pain pathways and stem cells in endometriosis pathogenesis.Molecular biology reports · 2025Review
- WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Heterologous): heterologous rodent models.Molecular human reproduction · 2025Review
- Prospects for potential therapy targeting immune‑associated factors in endometriosis (Review).Molecular medicine reports · 2025Review
- Multiple lesion inductions intensify central sensitization driven by neuroinflammation in a mouse model of endometriosis.bioRxiv : the preprint server for biology · 2025Article
- Effect of dietary patterns and nutritional supplementation in the management of endometriosis: a review.Frontiers in nutrition · 2025Review
- Metabolic reprogramming and M2 macrophage depletion define the microenvironment of adenomyosis.Frontiers in endocrinology · 2025Article
- Vitamin D and reproductive disorders: a comprehensive review with a focus on endometriosis.Reproductive health · 2024Review
- Immune pathway through endometriosis to ovarian cancer.World journal of clinical oncology · 2024Review
- The involvement of peritoneal GATA6Frontiers in immunology · 2024Article
- High-fat diets promote peritoneal inflammation and augment endometriosis-associated abdominal hyperalgesia.Frontiers in endocrinology · 2024Article
- HTATIP2 regulates arteriogenic activity in monocytes from patients with limb ischemia.JCI insight · 2023Article
- A protocol for creating endometriosis in rhesus macaques (Macaca mulatta).Journal of medical primatology · 2023Article
- High-fat diets promote peritoneal inflammation and augment endometriosis-associated abdominal hyperalgesia.bioRxiv : the preprint server for biology · 2023Article
- Review
- Spheroids as a model for endometriotic lesions.JCI insight · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endometriosis affects women of reproductive age, causing infertility and pain. Although immune cells are recruited in endometriotic lesions, their role is unclear. Tie2-expressing macrophages (TEMs) have nonredundant functions in promoting angiogenesis and growth of experimental tumors. Here we show that human TEMs infiltrate areas surrounding newly formed endometriotic blood vessels. We set up an ad hoc mouse model in which TEMs, and not Tie2-expressing endothelial cells, are targeted. We transplanted in wild-type recipients bone marrow cells expressing a suicide gene (Herpes simplex virus type 1 thymidine kinase) under the Tie2 promoter/enhancer. TEMs infiltrated endometriotic lesions. TEM depletion by ganciclovir administration arrested the growth of established lesions, without toxicity. Lesion architecture was disrupted, with: i) loss of glandular organization, ii) reduced neovascularization, and iii) activation of caspase 3 in CD31(+) endothelial cells. Thus, TEMs are important for maintaining the viability of newly formed vessels and represent a potential therapeutic target in endometriosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.