ArticleJournal of endodontics2011
Antibiotic resistance in primary and persistent endodontic infections.
Article in Journal of endodontics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evidence-based clinical practice guideline on antibiotic use for the urgent management of pulpal- and periapical-related dental pain and intraoral swelling: A report from the American Dental Association.Journal of the American Dental Association (1939) · 2019Guideline
- Bioactive peptides in Endodontic infections: The Good, The Bad, and The Ugly.Probiotics and antimicrobial proteins · 2026Review
- Antibacterial Effect of Cannabinoids on Bacteria Associated with Persistent Endodontic Infections.International journal of molecular sciences · 2025Article
- Synergistic antibacterial effect of ginsenoside Rh2 and calcium hydroxide on Enterococcus faecalis.Odontology · 2025Article
- Antimicrobial Silk Fibroin Methacrylated Scaffolds for Regenerative Endodontics.Journal of endodontics · 2024Article
- Chitosan-Gelatin Scaffolds Loaded with Different Antibiotic Formulations for Regenerative Endodontic Procedures Promote Biocompatibility and Antibacterial Activity.Journal of functional biomaterials · 2024Article
- Article
- The Outcome of Prescribing Antibiotics for the Management of Patients with Endodontic Infections.European endodontic journal · 2023Article
- Taxonomic Assignment-Based Genome Reconstruction from Apical Periodontal Metagenomes to Identify Antibiotic Resistance and Virulence Factors.Life (Basel, Switzerland) · 2023Article
- Natural monoterpenes-laden electrospun fibrous scaffolds for endodontic infection eradication.Odontology · 2023Article
- Antibiotic indication in endodontics by Colombian dentists with different levels of training: a survey.Acta odontologica latinoamericana : AOL · 2022Article
- Antimicrobial resistance in patients with odontogenic infections: A systematic scoping review of prospective and experimental studies.Journal of clinical and experimental dentistry · 2022Article
- Prevalence of Methicillin and β-Lactamase Resistant Pathogens Associated with Oral and Periodontal Disease of Children in Mymensingh, Bangladesh.Pathogens (Basel, Switzerland) · 2022Article
- Molecular characterization and antibacterial activity of oral antibiotics and copper nanoparticles against endodontic pathogens commonly related to health care-associated infections.Clinical oral investigations · 2021Article
- Photodynamic Therapy in Endodontics: A Helpful Tool to Combat Antibiotic Resistance? A Literature Review.Antibiotics (Basel, Switzerland) · 2021Review
- Root canal microorganisms and their antibiotic susceptibility in patients with persistent endodontic infections, with and without clinical symptoms.Odontology · 2021Article
- The Effects of Double Antibiotic Paste and Amoxicillin-clavulanate Paste Used in Endodontic Regeneration on Microhardness of Radicular Dentine: AnJournal of pharmacy & bioallied sciences · 2021Article
- Synergistic Effect of Plant Extracts on Endodontic Pathogens Isolated from Teeth with Root Canal Treatment Failure: An In Vitro Study.Antibiotics (Basel, Switzerland) · 2021Article
- Antibiotic Administration Along with Endodontic Therapy in the Republic of Croatia: a Pilot Study.Acta stomatologica Croatica · 2020Article
- Improving the Efficiency of Photodynamic Chemotherapy in Root Canals againstAntibiotics (Basel, Switzerland) · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
Abstract
introductionThe presence of antibiotic resistance genes in endodontic microorganisms might render the infection resistant to common antibiotics. The aims of this project were to identify selected antibiotic resistance genes in primary and persistent endodontic infections and to determine the effectiveness of contemporary endodontic procedures in eliminating bacteria with these genes.
methodsIn patients undergoing primary endodontic treatment or retreatment, the root canals were aseptically accessed and sampled before endodontic procedures as well as after contemporary chemomechanical preparation and medication with calcium hydroxide. Identification of the following antibiotic resistance genes was performed by using polymerase chain reaction: bla(TEM-1), cfxA, blaZ, tetM, tetW, tetQ, vanA, vanD, and vanE. Limited phenotypic identification and antibiotic susceptibility verification were also performed.
resultsOverall, there were 45 specimens available for analysis, 30 from primary and 15 from persistent endodontic infections. In preoperative specimens, only bla(TEM-1) was significantly more prevalent in primary versus persistent infections (P = .04). After contemporary treatment procedures, there was an overall reduction in prevalence of these genes (P < .001). bla(TEM-1) and tetW were significantly reduced (P < .05), cfxA, blaZ, and tetQ were eliminated, but there was no change in tetM. No specimens contained vanA, vanD, or vanE. Antibiotic susceptibility testing showed significant differences among the antibiotics (P < .001) and general concordance with the gene findings.
conclusionsbla(TEM)(-1) was more prevalent in primary than persistent infections. Vancomycin resistance was not present. The genes identified were reduced with treatment except for tetM. Genetic testing might be useful as a screening tool for antibiotic resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.