ArticleVeterinary ophthalmology2011
The effect of dorzolamide 2% on circadian intraocular pressure in cats with primary congenital glaucoma.
Article in Veterinary ophthalmology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Effect of timolol maleate gel-forming solution on intraocular pressure, pupil diameter, and heart rate in normal and glaucomatous cats.Veterinary ophthalmology · 2016Trial
- Effects of topical corticosteroid administration on intraocular pressure in normal and glaucomatous cats.Veterinary ophthalmology · 2016Trial
- Effect of topical latanoprost 0.005% on intraocular pressure and pupil diameter in normal and glaucomatous cats.Veterinary ophthalmology · 2016Trial
- Topical Omidenepag Isopropyl Lowers Intraocular Pressure in Normal and Glaucomatous Cats: A Pilot Study.Veterinary ophthalmology · 2026Article
- Effects of Omidenepag Isopropyl Versus Latanoprost Eye Drops on Intraocular Pressure, Pupil Diameter, and Anterior Chamber Parameters in Normal Feline Eyes: A Pilot Study.Veterinary ophthalmology · 2026Article
- Effects of Telmisartan on Intraocular Pressure, Blood Pressure, and Ocular Perfusion Pressure in Normal and Glaucomatous Cats.Translational vision science & technology · 2024Article
- Aqueous Humor TGF-β2 and Its Association With Intraocular Pressure in a Naturally Occurring Large Animal Model of Glaucoma.Investigative ophthalmology & visual science · 2023Article
- Animal Model Contributions to Primary Congenital Glaucoma.Journal of ophthalmology · 2022Review
- Updates on the molecular genetics of primary congenital glaucoma (Review).Experimental and therapeutic medicine · 2020Review
- Sub-region-Specific Optic Nerve Head Glial Activation in Glaucoma.Molecular neurobiology · 2020Article
- The effects of topical dorzolamide 2% and brinzolamide 1%, either alone or combined with timolol 0.5%, on intraocular pressure, pupil diameter, and heart rate in healthy cats.Veterinary ophthalmology · 2020Article
- The post-natal development of intraocular pressure in normal domestic cats (Felis catus) and in feline congenital glaucoma.Experimental eye research · 2018Article
- Article
- Prevention of nocturnal elevation of intraocular pressure by gene transfer of dominant-negative RhoA in rats.JAMA ophthalmology · 2015Article
- Effects of unilateral topical administration of 0.5% tropicamide on anterior segment morphology and intraocular pressure in normal cats and cats with primary congenital glaucoma.Veterinary ophthalmology · 2011Article
- Feline glaucoma--a comprehensive review.Veterinary ophthalmology · 2011Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo determine the extent of fluctuation in circadian intraocular pressure (IOP) and the efficacy of topical dorzolamide 2% q 8 h in lowering IOP and blunting circadian fluctuation in IOP in glaucomatous cats. ANIMALS STUDIED: Seven adult cats with primary congenital glaucoma (PCG). PROCEDURES: Measurements of IOP and pupil diameter were obtained for both eyes (OU) of each cat q 4 h for 12 days. Cats were housed in a laboratory animal facility with a 12-h light:dark cycle. Baseline values were established for 2 days. For the next 5 days, placebo (1.4% polyvinyl alcohol) was administered OU q 8 h. Dorzolamide 2% was then administered OU q 8 h for a further 5 days. A multivariate mixed linear model was fitted to the data, with parameters estimated from a Bayesian perspective. The 4 am time point was selected as the reference for the purposes of comparisons.
resultsEstimated mean IOP for the reference time point pre-treatment was symmetric (about 33 mmHg OU). In all cats, IOP was significantly lower during the diurnal phase, relative to the 4 am measurements, with highest IOP observed 2-6 h after the onset of the dark phase. Circadian fluctuations in IOP were dampened during the treatment period. There was a significant decrease in IOP in all cats during the dorzolamide treatment period (estimated mean for the treatment period reference = 17.9 mmHg OU).
conclusionsTopical dorzolamide 2% q 8 h is effective in reducing IOP and IOP fluctuation in cats with PCG.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.