ArticleVector borne and zoonotic diseases (Larchmont, N.Y.)2012
Resistance to plague among black-tailed prairie dog populations.
Article in Vector borne and zoonotic diseases (Larchmont, N.Y.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Drivers of the likelihood of evolutionary rescue in response to novel infectious diseases.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Variation in Gene Expression Across Infection Status and Elevation in a Hawaiian Honeycreeper.Ecology and evolution · 2025Article
- Article
- Quantifying intraspecific variation in host resistance and tolerance to a lethal pathogen.The Journal of animal ecology · 2025Article
- Genetic diversity ofHeliyon · 2024Article
- Prairie dog responses to vector control and vaccination during an initialInternational journal for parasitology. Parasites and wildlife · 2024Article
- Polygenic plague resistance in the great gerbil uncovered by population sequencing.PNAS nexus · 2022Article
- Reevaluation of the Role of Blocked Oropsylla hirsuta Prairie Dog Fleas (Siphonaptera: Ceratophyllidae) in Yersinia pestis (Enterobacterales: Enterobacteriaceae) Transmission.Journal of medical entomology · 2022Article
- Exploring and Mitigating Plague for One Health Purposes.Current tropical medicine reports · 2022Article
- First Genome Sequence of the Gunnison's Prairie Dog (Cynomys gunnisoni), a Keystone Species and Player in the Transmission of Sylvatic Plague.Genome biology and evolution · 2020Article
- Differential plague susceptibility in species and populations of prairie dogs.Ecology and evolution · 2019Article
- Impact of Sylvatic Plague Vaccine on Non-target Small Rodents in Grassland Ecosystems.EcoHealth · 2018Article
- Human case of bubonic plague resulting from the bite of a wild Gunnison's prairie dog during translocation from a plague-endemic area.Zoonoses and public health · 2018Article
- Climatic and evolutionary drivers of phase shifts in the plague epidemics of colonial India.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Evaluation of Yersinia pestis Transmission Pathways for Sylvatic Plague in Prairie Dog Populations in the Western U.S.EcoHealth · 2016Review
- Genetic variation at the MHC DRB1 locus is similar across Gunnison's prairie dog (Cynomys gunnisoni) colonies regardless of plague history.Ecology and evolution · 2016Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
In some rodent species frequently exposed to plague outbreaks caused by Yersinia pestis, resistance to the disease has evolved as a population trait. As a first step in determining if plague resistance has developed in black-tailed prairie dogs (Cynomys ludovicianus), animals captured from colonies in a plague-free region (South Dakota) and two plague-endemic regions (Colorado and Texas) were challenged with Y. pestis at one of three doses (2.5, 250, or 2500 mouse LD50s). South Dakota prairie dogs were far more susceptible to plague than Colorado and Texas prairie dogs (p<0.001), with a mortality rate of nearly 100% over all doses. Colorado and Texas prairie dogs were quite similar in their response, with overall survival rates of 50% and 60%, respectively. Prairie dogs from these states were heterogeneous in their response, with some animals dying at the lowest dose (37% and 20%, respectively) and some surviving even at the highest dose (29% and 40%, respectively). Microsatellite analysis revealed that all three groups were distinct genetically, but further studies are needed to establish a genetic basis for the observed differences in plague resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.