ArticleHuman brain mapping2012
Filtering the reality: functional dissociation of lateral and medial pain systems during sleep in humans.
Article in Human brain mapping, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- A pharmaco-fMRI study on pain networks induced by electrical stimulation after sumatriptan injection.Experimental brain research · 2013Trial
- Article
- Fractal Similarity of Pain Brain Networks.Advances in neurobiology · 2024Article
- Characterizing functional modules in the human thalamus: coactivation-based parcellation and systems-level functional decoding.Brain structure & function · 2023Review
- Intracortical Functional Connectivity Predicts Arousal to Noxious Stimuli during Sleep in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- [Pain and epilepsy : A clinical, neuroanatomical and pathophysiological review].Schmerz (Berlin, Germany) · 2018Article
- Concussion/mild traumatic brain injury-related chronic pain in males and females: A diagnostic modelling study.Medicine · 2017Article
- Sleep spindles and human cortical nociception: a surface and intracerebral electrophysiological study.The Journal of physiology · 2015Article
- Interactive effects of pain and arousal state on heart rate and cortical activity in the mouse anterior cingulate and somatosensory cortices.Neurobiology of pain (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Behavioral reactions to sensory stimuli during sleep are scarce despite preservation of sizeable cortical responses. To further understand such dissociation, we recorded intracortical field potentials to painful laser pulses in humans during waking and all-night sleep. Recordings were obtained from the three cortical structures receiving 95% of the spinothalamic cortical input in primates, namely the parietal operculum, posterior insula, and mid-anterior cingulate cortex. The dynamics of responses during sleep differed among cortical sites. In sleep Stage 2, evoked potential amplitudes were similarly attenuated relative to waking in all three cortical regions. During paradoxical, or rapid eye movements (REM), sleep, opercular and insular potentials remained stable in comparison with Stage 2, whereas the responses from mid-anterior cingulate abated drastically, and decreasing below background noise in half of the subjects. Thus, while the lateral operculo-insular system subserving sensory analysis of somatic stimuli remained active during paradoxical-REM sleep, mid-anterior cingulate processes related to orienting and avoidance behavior were suppressed. Dissociation between sensory and orienting-motor networks might explain why nociceptive stimuli can be either neglected or incorporated into dreams without awakening the subject.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.