ArticleHuman brain mapping2012
Different duration of at-risk mental state associated with neurofunctional abnormalities. A multimodal imaging study.
Article in Human brain mapping, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Do subjects at clinical high risk for psychosis differ from those with a genetic high risk?--A systematic review of structural and functional brain abnormalities.Current medicinal chemistry · 2013Pooled it
- Neuroanatomical maps of psychosis onset: voxel-wise meta-analysis of antipsychotic-naive VBM studies.Schizophrenia bulletin · 2012Pooled it
- Neural effects of green tea extract on dorsolateral prefrontal cortex.European journal of clinical nutrition · 2012Trial
- Brain Markers of Resilience to Psychosis in High-Risk Individuals: A Systematic Review and Label-Based Meta-Analysis of Multimodal MRI Studies.Brain sciences · 2025Review
- Translational application of neuroimaging in major depressive disorder: a review of psychoradiological studies.Frontiers of medicine · 2021Review
- Structural and functional imaging markers for susceptibility to psychosis.Molecular psychiatry · 2020Review
- Voxel-Based Morphometry Correlates of an Agitated-Aggressive Syndrome in the At-Risk Mental State for Psychosis and First Episode Psychosis.Scientific reports · 2018Article
- Article
- Acute Effects of Glucose and Fructose Administration on the Neural Correlates of Cognitive Functioning in Healthy Subjects: A Pilot Study.Frontiers in psychiatry · 2018Article
- Age-related brain structural alterations as an intermediate phenotype of psychosis.Journal of psychiatry & neuroscience : JPN · 2017Article
- Impact of polygenic schizophrenia-related risk and hippocampal volumes on the onset of psychosis.Translational psychiatry · 2016Article
- Altering the course of schizophrenia: progress and perspectives.Nature reviews. Drug discovery · 2016Review
- Multimodal fusion of brain imaging data: A key to finding the missing link(s) in complex mental illness.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2016Article
- Hyperactivity of caudate, parahippocampal, and prefrontal regions during working memory in never-medicated persons at clinical high-risk for psychosis.Schizophrenia research · 2016Article
- Meta-Analysis of Functional Neuroimaging and Cognitive Control Studies in Schizophrenia: Preliminary Elucidation of a Core Dysfunctional Timing Network.Frontiers in psychology · 2016Article
- Alterations in the hippocampus and thalamus in individuals at high risk for psychosis.NPJ schizophrenia · 2016Article
- Psychotic Experiences, Working Memory, and the Developing Brain: A Multimodal Neuroimaging Study.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Baseline brain perfusion and brain structure in patients with major depression: a multimodal magnetic resonance imaging study.Journal of psychiatry & neuroscience : JPN · 2015Article
- Lack of Evidence for Regional Brain Volume or Cortical Thickness Abnormalities in Youths at Clinical High Risk for Psychosis: Findings From the Longitudinal Youth at Risk Study.Schizophrenia bulletin · 2015Article
- Classification of first-episode psychosis: a multi-modal multi-feature approach integrating structural and diffusion imaging.Journal of neural transmission (Vienna, Austria : 1996) · 2015Article
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesNeurofunctional alterations are correlates of vulnerability to psychosis, as well as of the disorder itself. How these abnormalities relate to different probabilities for later transition to psychosis is unclear. We investigated vulnerability- versus disease-related versus resilience biomarkers of psychosis during working memory (WM) processing in individuals with an at-risk mental state (ARMS). EXPERIMENTAL
designPatients with "first-episode psychosis" (FEP, n = 21), short-term ARMS (ARMS-ST, n = 17), long-term ARMS (ARMS-LT, n = 16), and healthy controls (HC, n = 20) were investigated with an n-back WM task. We examined functional magnetic resonance imaging (fMRI) and structural magnetic resonance imaging (sMRI) data in conjunction using biological parametric mapping (BPM) toolbox. PRINCIPAL OBSERVATIONS: There were no differences in accuracy, but the FEP and the ARMS-ST group had longer reaction times compared with the HC and the ARMS-LT group. With the 2-back > 0-back contrast, we found reduced functional activation in ARMS-ST and FEP compared with the HC group in parietal and middle frontal regions. Relative to ARMS-LT individuals, FEP patients showed decreased activation in the bilateral inferior frontal gyrus and insula, and in the left prefrontal cortex. Compared with the ARMS-LT, the ARMS-ST subjects showed reduced activation in the right inferior frontal gyrus and insula. Reduced insular and prefrontal activation was associated with gray matter volume reduction in the same area in the ARMS-LT group.
conclusionsThese findings suggest that vulnerability to psychosis was associated with neurofunctional alterations in fronto-temporo-parietal networks in a WM task. Neurofunctional differences within the ARMS were related to different duration of the prodromal state and resilience factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.