ArticleParasitology research2012
Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plants.
Article in Parasitology research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- The anti-Trypanosoma activities of medicinal plants: A systematic review of the literature.Veterinary medicine and science · 2022Pooled it
- Amazonian useful plants described in the book "Le Pays des Amazones" (1885) of the Brazilian propagandist Baron de Santa-Anna Nery: a historical and ethnobotanical perspective.Journal of ethnobiology and ethnomedicine · 2024Article
- In Vitro Anti-Molecules (Basel, Switzerland) · 2024Article
- Comprehensive chemical profiling of Bassia indica Wight. aerial parts extract using UPLC-ESI-MS/MS, and its antiparasitic activity in Trichinella spiralis infected mice: in silico supported in vivo study.BMC complementary medicine and therapies · 2023Article
- Bioactive Potential: A Pharmacognostic Definition through the Screening of FourMolecules (Basel, Switzerland) · 2022Article
- Effects of Two Natural Bisbenzylisoquinolines, Curine and Guattegaumerine, Extracted fromMolecules (Basel, Switzerland) · 2022Article
- Trypanocidal Essential Oils: A Review.Molecules (Basel, Switzerland) · 2020Review
- A critical review: traditional uses, phytochemistry, pharmacology and toxicology ofPhytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2020Review
- Ethnobotany of Mexican and northern Central American cycads (Zamiaceae).Journal of ethnobiology and ethnomedicine · 2019Article
- In vitro anthelmintic assessment of selected phytochemicals against Hymenolepis diminuta, a zoonotic tapeworm.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2016Article
- Antileishmanial effect of mevastatin is due to interference with sterol metabolism.Parasitology research · 2015Article
- In vitro anti-Trichomonas vaginalis activity of Pistacia lentiscus mastic and Ocimum basilicum essential oil.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2015Article
- Trypanocidal, trichomonacidal and cytotoxic components of cultivated Artemisia absinthium Linnaeus (Asteraceae) essential oil.Memorias do Instituto Oswaldo Cruz · 2015Article
- Antileishmanial Potential of Tropical Rainforest Plant Extracts.Medicines (Basel, Switzerland) · 2014Article
- Antioxidant Content, Antioxidant Activity, and Antibacterial Activity of Five Plants from the Commelinaceae Family.Antioxidants (Basel, Switzerland) · 2014Article
- Antileishmanial, toxicity, and phytochemical evaluation of medicinal plants collected from Pakistan.BioMed research international · 2014Article
- Matching the power of high throughput screening to the chemical diversity of natural products.Natural product reports · 2013Review
- Inhibitory effect of Ferula asafoetida L. (Umbelliferae) on Blastocystis sp. subtype 3 growth in vitro.Parasitology research · 2012Article
- Anthelmintic activity of medicinal plants used in Côte d'Ivoire for treating parasitic diseases.Parasitology research · 2012Article
- Anti-Trichomonas vaginalis activity of saponins from Quillaja, Passiflora, and Ilex species.Parasitology research · 2012Article
Corrections and comments
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Authors and funding
8 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracts (34) from eight plant species of the Peruvian Amazonia currently used in traditional Peruvian medicine, mostly as antileishmanial remedies and also as painkiller, antiseptic, antipyretic, anti-inflamatory, antiflu, astringent, diuretic, antipoison, anticancerous, antiparasitic, insecticidal, or healing agents, have been tested for their antileishmanial, antitrypanosomal, and cytotoxic activity. Plant species were selected based on interviews conducted with residents of rural areas. The different plant parts were dried, powdered, and extracted by maceration with different solvents (hexane, chloroform, and 70% ethanol-water). These extracts were tested on promastigote forms of Leishmania infantum strain PB75, epimastigote forms of Trypanosoma cruzi strain Y, and the mammalian CHO cell line. Parasite viability and nonspecific cytotoxicity were analyzed by a modified MTT colorimetric assay method. The isolation and identification of pure compounds from selected extracts were performed by column chromatography, gas chromatography mass spectrometry (GC-MS; mixtures), spectroscopic techniques [MS, infrared (IR), ultraviolet (UV)], and mono and two-dimensional (1)H and (13)C nuclear magnetic resonance (NMR; COSY, HSQC, NOESY) experiments. Chondodendron tomentosum bark and Cedrela odorata were the most active extracts against Leishmania, while C. odorata and Aristoloquia pilosa were the most active against Trypanosoma, followed by Tabebuia serratifolia, Tradescantia zebrina, and Zamia ulei. Six compounds and two mixtures were isolated from Z. ulei [cycasin (1)], T. serratifolia {mixtures 1-2, and naphthoquinones 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione (2) and 2-(1-hydroxyethyl)-4H,9H-naphtho[2,3-b]furan-4,9-dione (3)}, and C. tomentosum [chondrocurine (4); (S,S')-12-O-methyl(+)-curine (5); and cycleanine (6)]. Four compounds and the two mixtures exhibited significant activity.
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