ArticleDigestive diseases and sciences2012
The -409 C/T genotype of PRSS1 protects against pancreatic cancer in the Han Chinese population.
Article in Digestive diseases and sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Pooled it
- Article
- PRSS1 mutation: a possible pathomechanism of pancreatic carcinogenesis and pancreatic cancer.Molecular medicine (Cambridge, Mass.) · 2019Article
- High serum trypsin levels and the -409 T/T genotype of PRSS1 gene are susceptible to neonatal sepsis.Inflammation · 2014Article
- Application of an electrochemical immunosensor with a MWCNT/PDAA modified electrode for detection of serum trypsin.Sensors (Basel, Switzerland) · 2014Article
- Human cationic trypsinogen (PRSS1) variants and chronic pancreatitis.American journal of physiology. Gastrointestinal and liver physiology · 2014Review
- Multiple gene mutations in patients with type 2 autoimmune pancreatitis and its clinical features.Central-European journal of immunology · 2014Article
- PRSS1_p.Leu81Met mutation results in autoimmune pancreatitis.World journal of gastroenterology · 2013Article
- Framework for interpretation of trypsin-antitrypsin imbalance and genetic heterogeneity in pancreatitis.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationReview
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsThe high mortality rate of pancreatic cancer is a bottleneck for further treatment with long-term efficacy. Thus, it is urgent to identify new methods to accurately predict the early onset of pancreatic cancer. We hypothesized that the different genotypes of cationic trypsinogen (PRSS1) gene could confer susceptibility and/or resistance to pancreatic cancer in the Han Chinese population.
methodsThe genotypes of PRSS1 were determined in 154 patients with pancreatic cancer and in a control group of 520 healthy individuals of Han Chinese descent. Clinical information was obtained, single-nucleotide polymorphisms (SNPs) of the PRSS1 gene were analyzed by direct sequencing, and the distribution of the genotypes were tested for Hardy-Weinberg equilibrium. Odds ratios and 95% confidence intervals were calculated by logistic regression analysis to estimate the associations between the different genotypes or haplotypes and the risk of pancreatic cancer.
resultsThree SNPs (-409 C/T, -204 A/C, and c.486 C/T) were identified. A case-control analysis revealed a 0.118-fold (95% CI: 0.037-0.653), 0.842-fold (95% CI: 0.177-4.010), and 0.750-fold (95% CI: 0.519-1.085) change in risk of developing pancreatic cancer for individuals harboring these SNPs, respectively. The individuals with the -409 C/T genotype tended to have a reduced risk compared to those who carried the -409 T/T genotype. A protective effect was observed for the C(-409)-A(-204)-C(486) haplotype compared to the T(-409)-A(-204)-T(486) haplotype (OR = 0.115, 95% CI: 0.016-0.849) or compared to the T(-409)-A(-204)-C(486) haplotype (OR = 0.090, 95% CI: 0.012-0.667). Serum levels of trypsin in patients with the -409 C/T genotype were only one-fourth that of those with the -409 T/T genotype and only one-third that of the healthy controls.
conclusionsThe -409 C/T genotype of PRSS1 was revealed to be a protective factor against pancreatic cancer in the Han Chinese population.
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