ArticleInternational journal of Alzheimer's disease2011
Mitochondria are related to synaptic pathology in Alzheimer's disease.
Article in International journal of Alzheimer's disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 54 citations in OpenAlex.
- Reframing Alzheimer's Disease Through a Redox-Metabolic Framework.International journal of molecular sciences · 2026Review
- Article
- Mitochondrial Alterations in Alzheimer's Disease: Insight from the 5xFAD Mouse Model.Molecular neurobiology · 2025Article
- HIV-1 gp120 protein promotes HAND through the calcineurin pathway activation.Mitochondrion · 2023Article
- Golgi apparatus, endoplasmic reticulum and mitochondrial function implicated in Alzheimer's disease through polygenic risk and RNA sequencing.Molecular psychiatry · 2023Article
- Article
- Pharmacokinetics and Pharmacodynamics of Key Components of a StandardizedAntioxidants (Basel, Switzerland) · 2022Article
- Mitochondrial complex I abnormalities is associated with tau and clinical symptoms in mild Alzheimer's disease.Molecular neurodegeneration · 2021Article
- Reassessment of Pioglitazone for Alzheimer's Disease.Frontiers in neuroscience · 2021Review
- Mitochondrial protein biogenesis in the synapse is supported by local translation.EMBO reports · 2020Article
- Perturbed mitochondria-ER contacts in live neurons that model the amyloid pathology of Alzheimer's disease.Journal of cell science · 2019Article
- Midget retinal ganglion cell dendritic and mitochondrial degeneration is an early feature of human glaucoma.Brain communications · 2019Article
- Genome-wide imaging association study implicates functional activity and glial homeostasis of the caudate in smoking addiction.BMC genomics · 2017Article
- L-3-n-butylphthalide Rescues Hippocampal Synaptic Failure and Attenuates Neuropathology in Aged APP/PS1 Mouse Model of Alzheimer's Disease.CNS neuroscience & therapeutics · 2016Article
- Mammillary Bodies in Alzheimer's Disease: A Golgi and Electron Microscope Study.American journal of Alzheimer's disease and other dementias · 2016Article
- The hypothalamus in Alzheimer's disease: a Golgi and electron microscope study.American journal of Alzheimer's disease and other dementias · 2015Article
- Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines.Human molecular genetics · 2013Article
- The influence of APOE and TOMM40 polymorphisms on hippocampal volume and episodic memory in old age.Frontiers in human neuroscience · 2013Article
- Letrozole Potentiates Mitochondrial and Dendritic Spine Impairments Induced by β Amyloid.Journal of aging research · 2013Article
- Mitochondrial dysfunction and cellular metabolic deficiency in Alzheimer's disease.Neuroscience bulletin · 2012Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Morphological alterations of mitochondria may play an important role in the pathogenesis of Alzheimer's disease, been associated with oxidative stress and Aβ-peptide-induced toxicity. We proceeded to estimation of mitochondria on electron micrographs of autopsy specimens of Alzheimer's disease. We found substantial morphological and morphometric changes of the mitochondria in the neurons of the hippocampus, the neocortex, the cerebellar cortex, the thalamus, the globus pallidus, the red nucleus, the locus coeruleus, and the climbing fibers. The alterations consisted of considerable changes of the cristae, accumulation of osmiophilic material, and modification of the shape and size. Mitochondrial alterations were prominent in neurons, which showed a depletion of dendritic spines and loss of dendritic branches. Mitochondrial alterations are not related with the accumulation of amyloid deposits, but are prominent whenever fragmentation of the Golgi apparatus exists. Morphometric analysis showed also that mitochondria are significantly reduced in neurons, which demonstrated synaptic pathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.