ArticleBioarchitecture2011
Oskar-induced endocytic activation and actin remodeling for anchorage of the Drosophila germ plasm.
Article in Bioarchitecture, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- JAK-STAT-dependent contact between follicle cells and the oocyte controls Drosophila anterior-posterior polarity and germline development.Nature communications · 2024Article
- Go with the flow - bulk transport by molecular motors.Journal of cell science · 2023Review
- Article
- Article
- Article
- Ooplasmic flow cooperates with transport and anchorage inThe Journal of cell biology · 2018Article
- Modeling microtubule-based transport and anchoring of mRNA.SIAM journal on applied dynamical systems · 2018Article
- Long Oskar Controls Mitochondrial Inheritance in Drosophila melanogaster.Developmental cell · 2016Article
- Single point mutation in Rabenosyn-5 in a female with intractable seizures and evidence of defective endocytotic trafficking.Orphanet journal of rare diseases · 2014Article
- mRNA localization in the Drosophila germline.RNA biology · 2014Review
- Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In many animals, germ-cell fate is specified by inheritance of the germ plasm, which is enriched in maternal RNAs and proteins. Assembly of the Drosophila germ (pole) plasm begins with the localization and translation of oskar (osk) RNA at the oocyte posterior pole. osk RNA produces two isoforms, long and short Osk. Short Osk recruits other pole plasm components, and long Osk restricts them to the oocyte cortex. Although molecular functions of long Osk remain mysterious, it is known to be involved in endocytic activation and actin cytoskeletal remodeling. We identified several vesicular trafficking machinery components that act downstream of long Osk in pole plasm assembly. These included the Rab5 effector protein Rabenosyn-5 (Rbsn-5) and the Golgi/endosomal protein Mon2, both of which were crucial for Osk-induced actin remodeling and the anchoring of pole plasm components. We propose that, in response to long Osk, the Rab5/Rbsn-5-dependent endocytic pathway promotes the formation of specialized vesicles, and Mon2 acts on these vesicles as a scaffold to instruct actin nucleators like Cappuccino and Spire to remodel the actin cytoskeleton, which anchors pole plasm components to the cortex. This mechanism may be applicable to the asymmetric localization of macromolecular structures such as protein-RNA complexes in other systems.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.