ArticleMolecular vision2011
Polymorphisms in steroidogenesis genes, sex steroid levels, and high myopia in the Taiwanese population.
Article in Molecular vision, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- The relationship between green space and myopia in children and adolescents: a systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- The Association Between Genetic Polymorphisms in Estrogen Receptor Genes and the Risk of Ocular Disease: A Meta-AnalysisTurkish journal of ophthalmology · 2020Pooled it
- Gene-Environment Interaction Loci Associated with Refractive Error: SCAMPI Analysis.Ophthalmology science · 2026Article
- Interaction effect of age and axial length-to-corneal radius ratio on myopia in children and adolescents: a cross-sectional study in China.Journal of translational medicine · 2025Article
- Computational approaches for identifications of altered ion channels in keratoconus.Eye (London, England) · 2025Article
- Myopic shift in female mice after ovariectomy.Scientific reports · 2024Article
- Study of myopia progression and risk factors in Hubei children aged 7-10 years using machine learning: a longitudinal cohort.BMC ophthalmology · 2024Article
- Inhibitory Effect of Jinkui Shenqi Pills on Glucocorticoid-Enhanced Axial Length Elongation in Experimentally Myopic Guinea Pigs.Chinese journal of integrative medicine · 2023Article
- The association between sleep duration and risk of myopia in Chinese school-aged children: a cross-sectional study.Sleep & breathing = Schlaf & Atmung · 2023Article
- Effects of Greenness on Myopia Risk and School-Level Myopia Prevalence Among High School-Aged Adolescents: Cross-sectional Study.JMIR public health and surveillance · 2023Article
- Role of single nucleotide polymorphisms of the HSD3B1 gene (rs6203 and rs33937873) in the prediction of prostate cancer risk.Molecular medicine reports · 2022Article
- A Novel missense mutation of COL2A1 gene in a large family with stickler syndrome type I.Journal of cellular and molecular medicine · 2022Article
- Longitudinal analysis of 5-year refractive changes in a large Japanese population.Scientific reports · 2022Article
- Sex Hormones, Growth Hormone, and the Cornea.Cells · 2022Review
- Sex Disparity in Myopia Explained by Puberty Among Chinese Adolescents From 1995 to 2014: A Nationwide Cross-Sectional Study.Frontiers in public health · 2022Article
- Myopia in India.Clinical ophthalmology (Auckland, N.Z.) · 2022Review
- Economic and educational factors played roles in the development of regional vision impairment in Shandong province, China.Scientific reports · 2021Article
- [Gender medicine in ophthalmology : The "small difference" between women and men].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2020Article
- Association of Visual Impairment With Economic Development Among Chinese Schoolchildren.JAMA pediatrics · 2019Article
- Systematic Analysis of Transcriptomic Profile of the Effects of Low Dose Atropine Treatment on Scleral Fibroblasts using Next-Generation Sequencing and Bioinformatics.International journal of medical sciences · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the relationship among single nucleotide polymorphisms (SNPs) in steroidogenesis enzyme genes, serum levels of sex steroids, and high myopia in Taiwanese male and female populations.
methodsA campus-based sample of 283 cases (145 males and 138 females) with high myopia and 280 controls (144 males and 136 females) with low myopia or emmetropia was studied. Estradiol, progesterone, and testosterone levels were determined using enzyme-linked immunosorbent assay kits. We genotyped six SNPs within five steroidogenesis enzyme genes (17 alpha-hydroxylase/17,20 lyase [CYP17A1], 3 beta-hydroxysteroid dehydrogenase [HSD3B1], 17 beta-hydroxysteroid dehydrogenase 1 [HSD17B1], steroid-5-alpha-reductase, alpha polypeptide 2 [SRD5A2], and aromatase [CYP19A1]) using polymerase chain reaction-restriction fragment length polymorphism methods. Student's t-tests, χ(2) tests, logistic regression, multifactor dimensionality reduction (MDR) methods, and ANOVA were used to determine significance.
resultsAn MDR analysis corroborated the synergistic genotype association and demonstrated that synergistic interaction between rs6203 (HSD3B1), rs10046 (CYP19A1), and sex might confer susceptibility to high myopia (p=0.019). In both male and female subjects, levels of testosterone were significantly higher in cases than in controls; in male subjects, the levels of estradiol were significantly higher and those of progesterone were significantly lower in cases (all p-values <0.001). The rs605059 (HSD17B1), with sex-gene interaction, showed association with estradiol levels in males (p=0.035) and testosterone levels in females (p=0.027).
conclusionsTestosterone levels correlate with high myopia, and interaction of steroidogenesis enzyme genes and sex may be a modulating factor in sex hormone metabolism and high-myopia risk.
Indexed as
Identifiers
21921981PMC3171499W2129278472What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.