Evidence map›Paper›PMID 21921685›Full record

ReviewVirulence

Staphylococcus aureus biofilms: properties, regulation, and roles in human disease.

Nathan K Archer, Mark J Mazaitis, J William Costerton, Jeff G Leid, Mary Elizabeth Powers, Mark E Shirtliff

Open access · goldAbstract readReview
In one paragraph

Review in Virulence. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 431 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
431citing papers in PubMed, 3 pooled it
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

431 citing papers in PubMed, 3 syntheses or guidelines pooled it, 976 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Prevention and Treatment ofPathogens (Basel, Switzerland) · 2026
    Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. The metabolic trap:Journal of medical microbiology · 2026
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Virulence Profiling of Multidrug-Resistant ClinicalMicrobial drug resistance (Larchmont, N.Y.) · 2026
    Article

371 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 5 countries.

Nathan K ArcherDepartment of Microbial Pathogenesis, Dental School, University of Maryland, Baltimore, MD, USA.
Mark J Mazaitis
J William Costerton
Jeff G Leid
Mary Elizabeth Powers
Mark E Shirtliff
University of Maryland, Baltimore · USFlagstaff Medical Center · USUniversity of Dental Medicine · MMUniversity of Pittsburgh · USUniversity of Waterloo · CA

Funding

Staphylococcus aureus biofilms: in vitro and in vivo studiesR01AI069568 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI SHIRTLIFF, MARK E · 2007 to 2011
$2.1M
NIAID NIH HHS R01 AI069568NIAID NIH HHS R01 AI69568-01A2
6 · The paper itself

Abstract

Increasing attention has been focused on understanding bacterial biofilms and this growth modality's relation to human disease. In this review we explore the genetic regulation and molecular components involved in biofilm formation and maturation in the context of the Gram-positive cocci, Staphylococcus aureus. In addition, we discuss diseases and host immune responses, along with current therapies associated with S. aureus biofilm infections and prevention strategies.

Indexed as

Bacterial Physiological PhenomenaBiofilmsHost-Pathogen InteractionsHumansModels, BiologicalStaphylococcal InfectionsStaphylococcus aureus

Identifiers

PMID21921685
PMCPMC3322633
OpenAlexW1531268983

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.