Evidence map›Paper›PMID 21921273›Full record

ReviewCirculation research2011

Cardiovascular pharmacogenomics.

Dan M Roden, Julie A Johnson, Stephen E Kimmel, Ronald M Krauss, Marisa Wong Medina, Alan Shuldiner, Russell A Wilke

Abstract readReview
In one paragraph

Review in Circulation research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Trial
  2. Review
  3. Treating Cardiovascular Disorders with Personalized Medicine.Cardiovascular & hematological disorders drug targets · 2025
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. A Brief Introduction to Management of LQTS.Reviews in cardiovascular medicine · 2022
    Article
  9. Variants inInternational journal of general medicine · 2021
    Article
  10. Article
  11. Genetic variations in the transcription factorsDrug design, development and therapy · 2019
    Article
  12. Review
  13. Pharmacogenetics in Cardiovascular Medicine.Current genetic medicine reports · 2016
    Article
  14. Review
  15. Pharmacogenetics of Potassium Channel Blockers.Cardiac electrophysiology clinics · 2016
    Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dan M RodenDepartments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232-0575, USA. dan.roden@vanderbilt.edu
Julie A Johnson
Stephen E Kimmel
Ronald M Krauss
Marisa Wong Medina
Alan Shuldiner
Russell A Wilke

Funding

Pharmacogenomics and Risk of Cardiovascular DiseaseU01HL069757 · NHLBI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI KRAUSS, RONALD M · 2001 to 2009
$24.7M
Pharmacogenomic Evaluation of Antihypertensive ResponsesU01GM074492 · NIGMS · UNIVERSITY OF FLORIDA · PI JOHNSON, JULIE A. · 2005 to 2014
$20.7M
Pharmacogenomics of Arrhythmia TherapyU19HL065962 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RODEN, DAN M · 2010 to 2014
$17.4M
Pharmacogenomics of Anti-platlet Intervention-2 (PAPI-2) StudyU01HL105198 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI SHULDINER, ALAN R. · 2010 to 2014
$13.6M
Pharmacogenomics and Risk of Cardiovascular DiseaseU19HL069757 · NHLBI · CHILDREN'S HOSPITAL & RES CTR AT OAKLAND · PI KRAUSS, RONALD M · 2010 to 2014
$12.8M
A randomized trial of interventions to improve warfarin adherenceR01HL090929 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KIMMEL, STEPHEN E., VOLPP, KEVIN G · 2008 to 2011
$3.1M
Alternative Splicing in Regulation of Cholesterol Synthesis and UptakeR01HL104133 · NHLBI · CHILDREN'S HOSPITAL & RES CTR AT OAKLAND · PI MEDINA, MARISA WONG · 2010 to 2014
$2.0M
Pharmacogenetics of obesity and endocannabinergic modulation (POEM)R01DK080007 · NIDDK · VANDERBILT UNIVERSITY · PI WILKE, RUSSELL A. · 2009 to 2012
$1.2M
NHLBI NIH HHS R01 HL090929NHLBI NIH HHS R01 HL104133NHLBI NIH HHS U01 HL069757NHLBI NIH HHS U01 HL105198NHLBI NIH HHS U19 HL065962NHLBI NIH HHS U19 HL069757NIDDK NIH HHS R01 DK080007NIGMS NIH HHS U01 GM074492
6 · The paper itself

Abstract

Patients vary in their responses to drug therapy, and some of that variability is genetically determined. This review outlines general approaches used to identify genetic variation that influences drug response. Examples from specific therapeutic areas are presented, such as cholesterol management, arrhythmias, heart failure, hypertension, warfarin anticoagulation, and antiplatelet agents. A brief view of potential pathways to implementation is presented.

Indexed as

Genetic VariationPharmacogeneticsBiological TransportBiotransformationCardiovascular AgentsCardiovascular DiseasesDrug Dosage CalculationsHumansPatient SelectionPrecision MedicineRisk AssessmentTreatment OutcomeCardiovascular Agents

Identifiers

PMID21921273
PMCPMC3201825

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.