ArticleGenome biology and evolution2011
The distribution of mobile genetic elements (MGEs) in MRSA CC398 is associated with both host and country.
Article in Genome biology and evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 88 citations in OpenAlex.
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- Evidence for the Dissemination to Humans of Methicillin-ResistantMicroorganisms · 2020Article
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- Simultaneous Nasal Carriage by Methicillin-Resistant and Methicillin SusceptiblePathogens (Basel, Switzerland) · 2020Article
- Staphylococci: Evolving Genomes.Microbiology spectrum · 2019Review
- Article
- CC398 Staphylococcus aureus subpopulations in Belgian patients.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- High Genetic Similarity of MRSA ST88 Isolated From Pigs and Humans in Kogi State, Nigeria.Frontiers in microbiology · 2018Article
- Acquisition of virulence factors in livestock-associated MRSA: Lysogenic conversion of CC398 strains by virulence gene-containing phages.Scientific reports · 2017Article
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Corrections and comments
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Authors and funding
10 authors at 5 institutions in 4 countries.
Funding
Abstract
Methicillin-resistant Staphylococcus aureus clonal complex (CC) 398 has emerged from pigs to cause human infections in Europe and North America. We used a new 62-strain S. aureus microarray (SAM-62) to compare genomes of isolates from three geographical areas (Belgium, Denmark, and Netherlands) to understand how CC398 colonizes different mammalian hosts. The core genomes of 44 pig isolates and 32 isolates from humans did not vary. However, mobile genetic element (MGE) distribution was variable including SCCmec. ϕ3 bacteriophage and human specificity genes (chp, sak, scn) were found in invasive human but not pig isolates. SaPI5 and putative ruminant specificity gene variants (vwb and scn) were common but not pig specific. Virulence and resistance gene carriage was host associated but country specific. We conclude MGE exchange is frequent in CC398 and greatest among populations in close contact. This feature may help determine epidemiological associations among isolates of the same lineage.
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