ArticleCurrent biology : CB2011
The snail repressor inhibits release, not elongation, of paused Pol II in the Drosophila embryo.
Article in Current biology : CB, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 40 citations in OpenAlex.
- Mitotic reactivation and transcriptional bursting govern transcriptional noise in the early Drosophila embryo.Development (Cambridge, England) · 2026Article
- Coordinated active repression operates via transcription factor cooperativity and multiple inactive promoter states in a developing organism.Nature communications · 2025Article
- Optogenetic manipulation of nuclear Dorsal reveals temporal requirements and consequences for transcription.Development (Cambridge, England) · 2025Article
- Optogenetic manipulation of nuclear Dorsal reveals temporal requirements and consequences for transcription.bioRxiv : the preprint server for biology · 2024Article
- Optogenetic dissection of transcriptional repression in a multicellular organism.Nature communications · 2024Article
- Rtf1 Transcriptionally Regulates Neonatal and Adult Cardiomyocyte Biology.Journal of cardiovascular development and disease · 2023Article
- Article
- Shadow enhancers modulate distinct transcriptional parameters that differentially effect downstream patterning events.Development (Cambridge, England) · 2022Article
- Integrative analysis reveals histone demethylase LSD1 promotes RNA polymerase II pausing.iScience · 2022Article
- Capicua is a fast-acting transcriptional brake.Current biology : CB · 2021Article
- A reaction-diffusion network model predicts a dual role of Cactus/IκB to regulate Dorsal/NFκB nuclear translocation in Drosophila.PLoS computational biology · 2021Article
- Dynamic patterning by morphogens illuminated by cis-regulatory studies.Development (Cambridge, England) · 2021Review
- Twist-dependent ratchet functioning downstream from Dorsal revealed using a light-inducible degron.Genes & development · 2020Article
- Hippo, TGF-β, and Src-MAPK pathways regulate transcription of the upd3 cytokine in Drosophila enterocytes upon bacterial infection.PLoS genetics · 2017Article
- mRNA quantification using single-molecule FISH in Drosophila embryos.Nature protocols · 2017Article
- Rapid Rates of Pol II Elongation in the Drosophila Embryo.Current biology : CB · 2017Article
- Complex cis-regulatory landscape of the insulin receptor gene underlies the broad expression of a central signaling regulator.Development (Cambridge, England) · 2016Article
- Initiation of diverse epigenetic states during nuclear programming of the Drosophila body plan.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Mitosis-associated repression in development.Genes & development · 2016Article
- Modulation of temporal dynamics of gene transcription by activator potency in the Drosophila embryo.Development (Cambridge, England) · 2015Article
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3 authors at 2 institutions in 1 country.
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Abstract
The development of the precellular Drosophila embryo is characterized by exceptionally rapid transitions in gene activity, with broadly distributed maternal regulatory gradients giving way to precise on/off patterns of gene expression within a one-hour window, between two and three hours after fertilization [1]. Transcriptional repression plays a pivotal role in this process, delineating sharp expression patterns (e.g., pair-rule stripes) within broad domains of gene activation. As many as 20 different sequence-specific repressors have been implicated in this process, yet the mechanisms by which they silence gene expression have remained elusive [2]. Here we report the development of a method for the quantitative visualization of transcriptional repression. We focus on the Snail repressor, which establishes the boundary between the presumptive mesoderm and neurogenic ectoderm [3]. We find that elongating Pol II complexes complete transcription after the onset of Snail repression. As a result, moderately sized genes (e.g., the 22 kb sog locus) are fully silenced only after tens of minutes of repression. We propose that this "repression lag" imposes a severe constraint on the regulatory dynamics of embryonic patterning and further suggest that posttranscriptional regulators, like microRNAs, are required to inhibit unwanted transcripts produced during protracted periods of gene silencing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.