ArticleJournal of biomechanics2011
Percutaneous osseointegrated prostheses for amputees: Limb compensation in a 12-month ovine model.
Article in Journal of biomechanics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Biomechanical Characterisation of Bone-anchored Implant Systems for Amputation Limb Prostheses: A Systematic Review.Annals of biomedical engineering · 2018Pooled it
- [Endo-exo prostheses following limb-amputation].Der Orthopade · 2015Trial
- Fluorapatite-Coated Percutaneous Osseointegrated Prostheses Limit Epidermal Downgrowth and Promote Periprosthetic Healing in a Weight-Bearing Sheep Model-A Preliminary Study.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Lower limb osseointegrated prosthetics: are we standing on the edge of a new era?Journal of orthopaedic surgery and research · 2026Review
- Biocompatibility Analysis of the Silver-Coated Microporous Titanium Implants Manufactured with 3D-Printing Technology.Nanomaterials (Basel, Switzerland) · 2024Article
- A Standardized Rat Model to Study Peri-implantitis of Transmucosal Osseointegrated Implants.Biomaterials research · 2024Article
- Toward higher-performance bionic limbs for wider clinical use.Nature biomedical engineering · 2023Review
- Neurological scoring and gait kinematics to assess functional outcome in an ovine model of ischaemic stroke.Frontiers in neurology · 2023Article
- Pressure sensing mat as an objective and sensitive tool for the evaluation of lameness in rabbits.PloS one · 2023Article
- [Transcutaneous osseointegrated prosthetic systems after major amputation of the lower extremity : A retrospective 3-year analysis].Der Orthopade · 2021Review
- Initial stability of a percutaneous osseointegrated endoprosthesis with proximal interlocking screws for transhumeral amputees.Clinical biomechanics (Bristol, Avon) · 2020Article
- Sex and Laterality Differences in Medullary Humerus Morphology.Anatomical record (Hoboken, N.J. : 2007) · 2019Article
- Variation in bone response to the placement of percutaneous osseointegrated endoprostheses: A 24-month follow-up in sheep.PloS one · 2019Article
- Implantation of an Intraosseous Transcutaneous Amputation Prosthesis Restoring Ambulation After Amputation of the Distal Aspect of the Left Tibia in an Arabian Tahr (Frontiers in veterinary science · 2019Article
- Evaluation of the temporary effect of physical vapor deposition silver coating on resistance to infection in transdermal skin and bone integrated pylon with deep porosity.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Article
- A Comparative Analysis of Standardised Threads for Use in Implants for Direct Skeletal Attachment of Limb Prosthesis: A Finite Element Analysis.Applied bionics and biomechanics · 2019Article
- Kinetics of individual limbs during level and slope walking with a unilateral transtibial bone-anchored prosthesis in the cat.Journal of biomechanics · 2018Article
- Osseointegrated Transcutaneous Device for Amputees: A Pilot Large Animal Model.Advances in orthopedics · 2018Article
- A 24-month evaluation of a percutaneous osseointegrated limb-skin interface in an ovine amputation model.Journal of materials science. Materials in medicine · 2017Article
- New developments in prosthetic arm systems.Orthopedic research and reviews · 2016Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Percutaneous osseointegrated prostheses are being investigated as an alternative strategy to attach prosthetic limbs to patients. Although the use of these implants has shown to be promising in clinical trials, the ability to maintain a skin seal around an osseointegrated implant interface is a major challenge to prevent superficial and deep periprosthetic infections. The specific aim of this study was to establish a translational load-bearing ovine model to assess postoperative limb compensation and gait symmetry following a percutaneous osseointegrated implant. We tested the following hypotheses: (1) the animals would return to pre-amputation limb loads within 12-months; (2) the animals would return to a symmetrical gait pattern (stride length and time in stance) within 12-months. The results demonstrated that one month following surgery, the sheep loaded their amputated limb to a mean value of nearly 80% of their pre-amputation loading condition; by 12-months, this mean had dropped to approximately 74%. There was no statistical differences between the symmetry of the amputated forelimb and the contralateral forelimb at any time point for the animals stride length or the time spent in the stance phase of their gait cycle. Thus, the data showed that while the animals maintained symmetric gait patterns, they did not return to full weight-bearing after 12-months. The results of this study showed that a large animal load-bearing model had a symmetric gait and was weight bearing for up to 12 months. While the current investigation utilizes an ovine model, the data show that osseointegrated implant technology with postoperative follow-up can help our human patients return to symmetric gait and maintain an active lifestyle, leading to an improvement in their quality of life following amputation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.