ArticleBehavioural brain research2012
In search of optimal fear inducing stimuli: Differential behavioral responses to computer animated images in zebrafish.
Article in Behavioural brain research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed.
- How to Make Your Fish Work for You: Tips from Ethology and Ecology for Finding Appropriate Unconditioned Stimuli for Learning Studies withAnimals : an open access journal from MDPI · 2026Article
- Comparative analysis of zebrafish fear responses to eight different fish species using three-dimensional locomotion-tracking assays.Biology open · 2025Article
- The importance of understanding the ethology and ecology of the zebrafish, and of other fish species, in experimental research.Biologia futura · 2025Review
- Behavioral and Biochemical Insights into the Therapeutic Potential of Mitocurcumin in a Zebrafish-Pentylenetetrazole (PTZ) Epilepsy Model.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Whole-brain mapping in adult zebrafish and identification of a novel tank test functional connectome.bioRxiv : the preprint server for biology · 2024Article
- Individual differences in the boldness of female zebrafish are associated with alterations in serotonin function.The Journal of experimental biology · 2024Article
- Individual differences in the boldness of female zebrafish are associated with alterations in serotonin function.bioRxiv : the preprint server for biology · 2024Article
- Simulating individual movement in fish.Scientific reports · 2023Article
- Neural Circuit Mechanisms Involved in Animals' Detection of and Response to Visual Threats.Neuroscience bulletin · 2023Review
- Behavioral Effects of Buspirone in Juvenile Zebrafish of Two Different Genetic Backgrounds.Toxics · 2022Article
- The effect of fish density and tank size on the behavior of adult zebrafish: A systematic analysis.Frontiers in behavioral neuroscience · 2022Article
- Zebrafish Tools for Deciphering Habenular Network-Linked Mental Disorders.Biomolecules · 2021Review
- Zebrafish as a Useful Tool in the Research of Natural Products With Potential Anxiolytic Effects.Frontiers in behavioral neuroscience · 2021Review
- Translating Neurobehavioral Toxicity Across Species From Zebrafish to Rats to Humans: Implications for Risk Assessment.Frontiers in toxicology · 2021Review
- Contributions of Luminance and Motion to Visual Escape and Habituation in Larval Zebrafish.Frontiers in neural circuits · 2021Article
- Design and development of a robotic predator as a stimulus in conditioned place aversion for the study of the effect of ethanol and citalopram in zebrafish.Behavioural brain research · 2020Article
- Paternal exposure to a common herbicide alters the behavior and serotonergic system of zebrafish offspring.PloS one · 2020Article
- Anxiolytic and Antidepressant Effects of the Hydroethanolic Extract from the Leaves ofPharmaceuticals (Basel, Switzerland) · 2019Article
- Zebrafish Adjust Their Behavior in Response to an Interactive Robotic Predator.Frontiers in robotics and AI · 2019Article
- Stress test of a biological early warning system with zebrafish (Danio rerio).Ecotoxicology (London, England) · 2017Article
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2 authors.
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Abstract
Zebrafish has been gaining popularity in behavioral genetics and behavioral neuroscience as this species offers an excellent compromise between system complexity and practical simplicity for mechanistic analyses of brain and behavior function. Recently, a number of studies started to investigate methods with which fear responses may be induced reliably in zebrafish. The ultimate goal of these studies has been to develop zebrafish models of pathological processes and to investigate the mechanisms of fear and to eventually translate the findings to the human clinic. Previously, animated image of a sympatric predator of zebrafish was shown to induce fear responses. Here we expand on this recently gained knowledge and investigate whether other moving images may induce more robust fear responses. The images investigated include the original sympatric predator, the Indian leaf fish, another sympatric predator, the needle fish, a bird silhouette moved on the side or above the tank, an expanding dot mimicking rapid approach of an object shown on the side and from above the tank, as well as non-fear inducing images including a single and a group of zebrafish. Our results indicate that although the sympatric predators do induce some fear responses, the other images, particularly the expanding dot but also the bird silhouette shown from above are more effective. The results also reveal a stimulus dependent motor pattern response repertoire of zebrafish demonstrating that perhaps univariate quantification methods may not be appropriate for uncovering the complexity of fear or anxiety related phenotypical changes in this species.
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