Trial reportThe British journal of nutrition2012
Equol production changes over time in pre-menopausal women.
Trial report in The British journal of nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Trial
- The relation of urinary estrogen metabolites with mammographic densities in premenopausal women.Cancer epidemiology · 2012Trial
- Urinary estrogen metabolites in two soy trials with premenopausal women.European journal of clinical nutrition · 2012Trial
- Soy foods and urinary isoprostanes: results from a randomized study in premenopausal women.Food & function · 2012Trial
- Urinary estrogen metabolites during a randomized soy trial.Nutrition and cancer · 2012Trial
- Converting Equol Nonproducers to Producers: A Systematic Review of Randomized Clinical Trials.Food science & nutrition · 2026Review
- Stability of equol production capability is associated with the diversity of the gut microbiota of the host: a prospective cohort study.BMC microbiology · 2026Article
- Safety assessment of (S)-Equol: Subchronic toxicity study in Sprague Dawley Rats.Toxicology reports · 2024Article
- Potential Protective Mechanisms of S-equol, a Metabolite of Soy Isoflavone by the Gut Microbiome, on Cognitive Decline and Dementia.International journal of molecular sciences · 2022Review
- Review
- Impact of Short-Term Isoflavone Intervention in Polycystic Ovary Syndrome (PCOS) Patients on Microbiota Composition and Metagenomics.Nutrients · 2020Article
- Daidzein Intake Is Associated with Equol Producing Status through an Increase in the Intestinal Bacteria Responsible for Equol Production.Nutrients · 2019Article
- Effect of S-equol and Soy Isoflavones on Heart and Brain.Current cardiology reviews · 2019Review
- Relationship of equol production between children aged 5-7 years and their mothers.European journal of nutrition · 2017Article
- Plasma equol concentration is not associated with breast cancer and fibrocystic breast conditions among women in Shanghai, China.Nutrition research (New York, N.Y.) · 2016Article
- Therapeutic perspectives of epigenetically active nutrients.British journal of pharmacology · 2015Review
- The role of colonic bacteria in the metabolism of the natural isoflavone daidzin to equol.Metabolites · 2015Review
- Absorption, distribution, metabolism, and excretion of isoflavonoids after soy intake.Archives of biochemistry and biophysics · 2014Review
- S-(-)equol production is developmentally regulated and related to early diet composition.Nutrition research (New York, N.Y.) · 2014Article
- S-(-)equol producing status not associated with breast cancer risk among low isoflavone-consuming US postmenopausal women undergoing a physician-recommended breast biopsy.Nutrition research (New York, N.Y.) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Equol (EQ) is a metabolite produced by gut bacteria through the chemical reduction of the soya isoflavone daidzein (DE), but only by 30-60% of the population. EQ is believed to provide benefits derived from soya intake and its production is widely viewed as a relatively stable phenomenon. In a randomised, cross-over intervention with soya foods, seventy-nine pre-menopausal women were challenged with a high-soya and a low-soya diet each for 6 months, separated by a 1-month washout period. Overnight urine was collected at three time points during each diet period and analysed for DE and EQ by liquid chromatography tandem MS. Remaining an EQ producer (EP) or non-producer (NP) or changing towards an EP or NP was assessed using an EQ:DE ratio of ≥0·018 combined with a DE threshold of ≥2 nmol/mg creatinine as a cut-off point. We observed 19 and 24% EP during the low-soya and high-soya diet periods, respectively, and found that 6-11% of our subjects changed EQ status 'within' each study period (on an average of 1·2 times), while 16% changed 'between' the two diet periods. The present finding challenges the widely held conviction that EQ production within an individual remains stable over time. The precise factors contributing to changes in EQ status, however, remain elusive and warrant further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.