ArticleAllergy2012
Increased expression of IRF4 and ETS1 in CD4+ cells from patients with intermittent allergic rhinitis.
Article in Allergy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- DNMT3A-mediated Methylation of IRF4 Alleviates Inflammatory Response in Allergic Rhinitis Mice.Applied biochemistry and biotechnology · 2026Article
- Single-cell RNA sequencing reveals immune cell alterations in patients with allergic rhinitis treated with Peiyuan Tong-qiao decoction.Biochemistry and biophysics reports · 2025Article
- Review
- Seminar: Scalable Preprocessing Tools for Exposomic Data Analysis.Environmental health perspectives · 2023Article
- Construction and analysis of a ceRNA network and patterns of immune infiltration in chronic rhinosinusitis with nasal polyps: based on data mining and experimental verification.Scientific reports · 2022Article
- Bach2 overexpression represses Th9 cell differentiation by suppressing IRF4 expression in systemic lupus erythematosus.FEBS open bio · 2021Observational
- Molecular Subtyping and Outlier Detection in Human Disease Using the Paraclique Algorithm.Algorithms · 2021Article
- Article
- Article
- LASSIM-A network inference toolbox for genome-wide mechanistic modeling.PLoS computational biology · 2017Article
- Alkaline Cytosolic pH and High Sodium Hydrogen Exchanger 1 (NHE1) Activity in Th9 Cells.The Journal of biological chemistry · 2016Article
- A generally applicable translational strategy identifies S100A4 as a candidate gene in allergy.Science translational medicine · 2014Article
- Genetic variants in PARP1 (rs3219090) and IRF4 (rs12203592) genes associated with melanoma susceptibility in a Spanish population.BMC cancer · 2013Article
- Highly interconnected genes in disease-specific networks are enriched for disease-associated polymorphisms.Genome biology · 2012Article
Corrections and comments
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Authors and funding
12 authors at 8 institutions in 4 countries.
Funding
Abstract
backgroundThe transcription factor (TF) IRF4 is involved in the regulation of Th1, Th2, Th9, and Th17 cells, and animal studies have indicated an important role in allergy. However, IRF4 and its target genes have not been examined in human allergy.
methodsIRF4 and its target genes were examined in allergen-challenged CD4(+) cells from patients with IAR, using combined gene expression microarrays and chromatin immunoprecipitation chips (ChIP-chips), computational target prediction, and RNAi knockdowns.
resultsIRF4 increased in allergen-challenged CD4(+) cells from patients with IAR, and functional studies supported its role in Th2 cell activation. IRF4 ChIP-chip showed that IRF4 regulated a large number of genes relevant to Th cell differentiation. However, neither Th1 nor Th2 cytokines were the direct targets of IRF4. To examine whether IRF4 induced Th2 cytokines via one or more downstream TFs, we combined gene expression microarrays, ChIP-chips, and computational target prediction and found a putative intermediary TF, namely ETS1 in allergen-challenged CD4(+) cells from allergic patients. ETS1 increased significantly in allergen-challenged CD4(+) cells from patients compared to controls. Gene expression microarrays before and after ETS1 RNAi knockdown showed that ETS1 induced Th2 cytokines as well as disease-related pathways.
conclusionsIncreased expression of IRF4 in allergen-challenged CD4(+) cells from patients with intermittent allergic rhinitis leads to activation of a complex transcriptional program, including Th2 cytokines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.