ArticleTissue engineering. Part A2012
Dual regulation of breast tubulogenesis using extracellular matrix composition and stromal cells.
Article in Tissue engineering. Part A, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Spatial Engineering of Mammary Epithelial Cell Cultures with 3D Bioprinting Reveals Growth Control by Branch Point Proximity.Journal of mammary gland biology and neoplasia · 2024Article
- Modeling Mammary Organogenesis from Biological First Principles: A Systems Biology Approach.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Designing Organoid Models to Monitor Cancer Progression, Plasticity and Resistance: The Right Set Up for the Right Question.Cancers · 2022Article
- Matrix Composition Modulates Vitamin D3's Effects on 3D Collagen Fiber Organization by MCF10A Cells.Tissue engineering. Part A · 2021Article
- BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models.Nature communications · 2021Article
- 3D organizational mapping of collagen fibers elucidates matrix remodeling in a hormone-sensitive 3D breast tissue model.Biomaterials · 2018Article
- Characterization of primary human mammary epithelial cells isolated and propagated by conditional reprogrammed cell culture.Oncotarget · 2018Article
- Characterization of MCF-12A cell phenotype, response to estrogens, and growth in 3D.Cancer cell international · 2018Article
- Modeling mammary organogenesis from biological first principles: Cells and their physical constraints.Progress in biophysics and molecular biology · 2016Review
- A Hormone-responsive 3D Culture Model of the Human Mammary Gland Epithelium.Journal of visualized experiments : JoVE · 2016Article
- Article
- Hormonal regulation of epithelial organization in a three-dimensional breast tissue culture model.Tissue engineering. Part C, Methods · 2014Article
- From single cells to tissues: interactions between the matrix and human breast cells in real time.PloS one · 2014Article
- Building risk-on-a-chip models to improve breast cancer risk assessment and prevention.Integrative biology : quantitative biosciences from nano to macro · 2013Review
- Does cancer start in the womb? altered mammary gland development and predisposition to breast cancer due to in utero exposure to endocrine disruptors.Journal of mammary gland biology and neoplasia · 2013Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epithelial-mesenchymal interactions during embryogenesis are critical in defining the phenotype of tissues and organs. The initial elongation of the mammary bud represents a central morphological event requiring extensive epithelial-mesenchymal crosstalk. The precise mechanism orchestrating this outgrowth is still unknown and mostly animal models have been relied upon to explore this process. Highly tunable three-dimensional (3D) culture models are a complementary approach to address the question of phenotypic determination. Here, we used a 3D in vitro culture to study the roles of stromal cells and extracellular matrix components during mammary tubulogenesis. Fibroblasts, adipocytes, and type I collagen actively participated in this process, whereas reconstituted basement membrane inhibited tubulogenesis by affecting collagen organization. We conclude that biochemical and biomechanical signals mediate the interaction between cells and matrix components and are necessary to induce tubulogenesis in vitro.
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Registered trials
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