ArticleJournal of clinical laboratory analysis2011
Method of stabilizing blood for the determination of methemoglobin.
Article in Journal of clinical laboratory analysis, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Preliminary investigation of circulating methaemoglobin fraction in cats with sepsis: a small exploratory study.Journal of feline medicine and surgery · 2026Article
- Nitrite Dipstick Urinalysis as a Point-Of-Care Test for Sodium Nitrite Poisoning.Therapeutic drug monitoring · 2026Article
- Accurate Estimation of Methemoglobin and Oxygen Saturation in Skin Tissue Using Diffuse Reflectance Spectroscopy and Artificial Intelligence.Journal of biophotonics · 2025Article
- Article
- RETRACTED: Systematic Review of Fatal Sodium Nitrite Ingestion Cases: Toxicological and Forensic Implications.Toxics · 2024Review
- Variability of extracellular vesicle release during storage of red blood cell concentrates is associated with differential membrane alterations, including loss of cholesterol-enriched domains.Frontiers in physiology · 2023Article
- Parallel Potentiometric and Capacitive Response in a Water-Gate Thin Film Transistor Biosensor at High Ionic Strength.Sensors (Basel, Switzerland) · 2021Article
- Detection of methaemoglobinaemia and its application in 'poppers' abuse: maintaining the right balance between reduction and autooxidation during storage.International journal of legal medicine · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Methemoglobin (MetHb) is a significant clinical problem for some poisonings. Its measurement is a problem as both formation and reduction of MetHb can occur even after sampling with time. The objective of this study was to discover a method to stabilize the blood samples for the determination of MetHb. First, hemolysates were prepared by diluting the MetHb blood samples with phosphate buffers under different pH values. The samples were stored at 4-8 °C and a day-to-day variability in the amount of MetHb was determined using the method described by Evelyn and Malloy. The results show that there is a significantchange in the amount of MetHbstored in both KH2PO4/Na2HPO4 and KH2PO4/Na2HPO4 .2H2O buffer solutions at pH of 6.7 and 6.9. Buffer solution containing phosphate composition of KH2PO4/Na2HPO4 ·2H2O (pH=7.0) gives relatively stable values for MetHb during the storage and the amount of MetHb samples in the buffer solution retain constant up to 9 days. Therefore, stabilized MetHb blood samples can be prepared using KH2PO4/Na2HPO4 ·2H2O buffer solution (pH=7) with non-ionic detergent and the samples can be stored for several days at 4-8 °C.
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