ArticleAdvances and applications in bioinformatics and chemistry : AABC2010
Estimating affinities of calcium ions to proteins.
Article in Advances and applications in bioinformatics and chemistry : AABC, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Immobilization of Baeyer-Villiger monooxygenase from acetone grown Fusarium sp.Biotechnology letters · 2022Article
- Signaling domain of Sonic Hedgehog as cannibalistic calcium-regulated zinc-peptidase.PLoS computational biology · 2014Article
- Prediction and analysis of canonical EF hand loop and qualitative estimation of Ca²⁺ binding affinity.PloS one · 2014Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Ca(2+)-ions have a range of affinities to different proteins, depending on the various functions of these proteins. This makes the determination of Ca(2+)-protein affinities an interesting subject for functional studies. We have investigated the performance of two methods - Fold-X and AutoDock vina - in the prediction of Ca(2+)-protein affinities. Both methods, although based on different energy functions, showed virtually the same correlation with experimental affinities. Guided by insight from experiment, we further derived a simple linear model based on the solvent accessible surface of Ca(2+) that had practically the same performance in terms of absolute errors as the more complex docking methods.
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