ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2012
Distinct contributions of dopamine in the dorsolateral striatum and nucleus accumbens shell to the reinforcing properties of cocaine.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 75 citations in OpenAlex.
- From bugs to behavior: targeting the gut-brain interface for addiction therapeutics.Gut microbes · 2025Review
- Nicotine enhances the ability of cues to control behavior and evoke dopamine release in the dorsolateral striatum.The Journal of pharmacology and experimental therapeutics · 2025Article
- Delineating anticipatory arousal from reward consumption: evaluating fixed-intervals in cocaine seeking-taking response chains.Psychopharmacology · 2025Article
- Cocaine-Induced Remodeling of the Rat Brain Peptidome: Quantitative Mass Spectrometry Reveals Anatomically Specific Patterns of Cocaine-Regulated Peptide Changes.ACS chemical neuroscience · 2025Article
- Cocaine self-administration behavior is associated with subcortical and cortical morphometry measures in individuals with cocaine use disorder.The American journal of drug and alcohol abuse · 2024Article
- Nucleus accumbens shell neurons' early sensitivity to cocaine is associated with future increases in drug intake.Addiction neuroscience · 2023Article
- Interaction between maternal immune activation and peripubertal stress in rats: impact on cocaine addiction-like behaviour, morphofunctional brain parameters and striatal transcriptome.Translational psychiatry · 2023Article
- Acute and protracted abstinence from methamphetamine bidirectionally changes intrinsic excitability of indirect pathway spiny projection neurons in the dorsomedial striatum.Scientific reports · 2022Article
- Nicotine self-administration and ERK signaling are altered in RasGRF2 knockout mice.Frontiers in pharmacology · 2022Article
- Dynamic regulation of oxytocin neuronal circuits in the sequential processes of prosocial behavior in rodent models.Current research in neurobiology · 2021Review
- Revealing oral microbiota composition and functionality associated with heavy cigarette smoking.Journal of translational medicine · 2020Article
- Overexpression of ASIC1A in the nucleus accumbens of rats potentiates cocaine-seeking behavior.Addiction biology · 2020Article
- Ultrahigh-resolution MRI reveals structural brain differences in serotonin transporter knockout rats after sucrose and cocaine self-administration.Addiction biology · 2020Article
- The Inhibition of RasGRF2, But Not RasGRF1, Alters Cocaine Reward in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Sex-dependent regulation of social reward by oxytocin receptors in the ventral tegmental area.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Neuronal scaffolding protein spinophilin is integral for cocaine-induced behavioral sensitization and ERK1/2 activation.Molecular brain · 2019Article
- Effects of long-term high-fat food or methamphetamine intake and serotonin 2C receptors on reversal learning in female rhesus macaques.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Role of oxytocin in the ventral tegmental area in social reinforcement.Psychoneuroendocrinology · 2018Article
- A neuronal activation correlate in striatum and prefrontal cortex of prolonged cocaine intake.Brain structure & function · 2017Article
- Strain and cocaine-induced differential opioid gene expression may predispose Lewis but not Fischer rats to escalate cocaine self-administration.Neuropharmacology · 2016Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Dopaminergic neurotransmission in the dorsal and ventral striatum is thought to be involved in distinct aspects of cocaine addiction. Ventral striatal dopamine mediates the acute reinforcing properties of cocaine, whereas dopamine in the dorsolateral striatum (DLS) is thought to become involved in later stages of the addiction process to mediate well-established cue-controlled drug seeking. However, it is unclear whether the DLS also has a role in the reinforcing properties of cocaine itself. Therefore, we systematically investigated the involvement of dopamine in dorsal and ventral striatal regions in cocaine self-administration, using various schedules of reinforcement in animals with limited drug taking experience. Intra-DLS infusion of the dopamine receptor antagonist α-flupenthixol did not affect the acquisition of cocaine self-administration, increased cocaine self-administration under a fixed ratio-1 (FR-1) schedule of reinforcement, caused a rightward and downward shift of the dose-response curve of cocaine under an FR-1 schedule of reinforcement and decreased responding for cocaine under a progressive ratio (PR) schedule of reinforcement. Infusion of α-flupenthixol into the ventral nucleus accumbens (NAcc) shell inhibited the acquisition of cocaine self-administration, reduced responding for the drug under FR-1 and PR schedules of reinforcement, and caused a downward shift of the dose-response curve of cocaine self-administration under an FR-1 schedule of reinforcement. These data show that dopamine in both the DLS and NAcc shell is involved in cocaine reinforcement. We suggest that the DLS and the NAcc shell mediate somewhat distinct facets of the reinforcing properties of cocaine, related to its rewarding and motivational aspects, respectively.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.