ArticleKidney international2012
Acute removal of common sepsis mediators does not explain the effects of extracorporeal blood purification in experimental sepsis.
Article in Kidney international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Removal of Cytokines in Patients Undergoing Cardiac Surgery With CPB (The REMOTE Study)
Comparing the Cytokine Clearances of Pro-, and Anti-inflammatory Mediators, Chemokines and Complement in the COVID-19 Patients Treated With CytoSorb as Compared to the Same Patient Population Who do Not Receive Blood Purification Treatment
Dosing of Extracorporeal Cytokine Removal In Septic Shock (DECRISS): a Prospective, Randomized, Multicenter Clinical Trial
Innovative Solutions to Organ-substituting Technologies in the Treatment of Heart and Pulmonary Failure
Development of Innovative Technologies for the Treatment of Pulmonary and Heart Failure to Prolong Human's Life
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.
- Blood purification and mortality in sepsis: a meta-analysis of randomized trials.Critical care medicine · 2013Pooled it
- Extracorporeal cytokine elimination as rescue therapy in refractory septic shock: a prospective single-center study.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2017Trial
- Trial
- Ineffectiveness of hemoadsorption in large animals with abdominal sepsis: a randomized controlled porcine study.Intensive care medicine experimental · 2024Article
- Adjunctive Hemoadsorption Therapy with CytoSorb in Patients with Septic/Vasoplegic Shock: A Best Practice Consensus Statement.Journal of clinical medicine · 2023Review
- Kinetics of Bilirubin and Ammonia Elimination during Hemadsorption Therapy in Secondary Sclerosing Cholangitis Following ECMO Therapy and Severe COVID-19.Biomedicines · 2021Article
- Article
- The Use of CytoSorb Therapy in Critically Ill COVID-19 Patients: Review of the Rationale and Current Clinical Experiences.Critical care research and practice · 2021Review
- Hemoadsorption with CytoSorb in Septic Shock Reduces Catecholamine Requirements and In-Hospital Mortality: A Single-Center Retrospective 'Genetic' Matched Analysis.Biomedicines · 2020Article
- Cytokine removal in human septic shock: Where are we and where are we going?Annals of intensive care · 2019Review
- Hemoadsorption corrects hyperresistinemia and restores anti-bacterial neutrophil function.Intensive care medicine experimental · 2017Article
- Blood purification treatment initiated at the time of sepsis diagnosis effectively attenuates serum HMGB1 upregulation and improves patient prognosis.Experimental and therapeutic medicine · 2017Article
- Hemoadsorption treatment of patients with acute infective endocarditis during surgery with cardiopulmonary bypass - a case series.The International journal of artificial organs · 2017Article
- A bio-artificial renal epithelial cell system conveys survival advantage in a porcine model of septic shock.Journal of tissue engineering and regenerative medicine · 2017Article
- Endothelial bioreactor system ameliorates multiple organ dysfunction in septic rats.Intensive care medicine experimental · 2016Article
- Polystyrene-Divinylbenzene-Based Adsorbents Reduce Endothelial Activation and Monocyte Adhesion Under Septic Conditions in a Pore Size-Dependent Manner.Inflammation · 2016Article
- Effectiveness of Multiple Blood-Cleansing Interventions in Sepsis, Characterized in Rats.Scientific reports · 2016Article
- Broad spectrum immunomodulation using biomimetic blood cell margination for sepsis therapy.Lab on a chip · 2016Article
- Modeling and Hemofiltration Treatment of Acute Inflammation.Processes (Basel, Switzerland) · 2016Article
- A Neutrophil Phenotype Model for Extracorporeal Treatment of Sepsis.PLoS computational biology · 2015Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 2 countries.
Funding
Abstract
The effect of extracorporeal blood purification on clinical outcomes in sepsis is assumed to be related to modulation of plasma cytokine concentrations. To test this hypothesis directly, we treated rats that had a cecal ligation followed by puncture (a standard model of sepsis) with a modest dose of extracorporeal blood purification that did not result in acute changes in a panel of common cytokines associated with inflammation (TNF-α, IL-1β, IL-6, and IL-10). Pre- and immediate post-treatment levels of these cytokines were unchanged compared to the sham therapy of extracorporeal circulation without blood purifying sorbent. The overall survival to 7 days, however, was significantly better in animals that received extracorporeal blood purification compared to those with a sham procedure. This panel of common plasma cytokines along with alanine aminotransferase and creatinine was significantly lower 72 h following extracorporeal blood purification compared to sham-treated rats. Thus, the effects of this procedure on organ function and survival do not appear to be due solely to immediate changes in the usual measured circulating cytokines. These results may have important implications for the design and conduct of future trials in sepsis including defining alternative targets for extracorporeal blood purification and other therapies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.