ArticleBehavioural pharmacology2011
Neonatal exposure to the D1 agonist SKF38393 inhibits pair bonding in the adult prairie vole.
Article in Behavioural pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Mapping the cellular basis of species differences in oxytocin and dopamine receptor expression in the vole nucleus accumbens.Scientific reports · 2025Article
- Multi-Level Effects Driving Cognitive and Behavioral Variability among Prairie Voles: Insights into Reproductive Decision-Making from Biological Levels of Organization.Brain, behavior and evolution · 2022Review
- Familiarity and Mate Preference Assessment with the Partner Preference Test.Current protocols · 2021Article
- Effects of systemic endocannabinoid manipulation on social and exploratory behavior in prairie voles (Microtus ochrogaster).Psychopharmacology · 2021Article
- Stress, sensitive periods, and substance abuse.Neurobiology of stress · 2019Review
- Dopamine DBehavioural brain research · 2019Article
- Effects of pair bonding on dopamine D1 receptors in monogamous male titi monkeys (Callicebus cupreus).American journal of primatology · 2017Article
- Serotonin 1A agonism decreases affiliative behavior in pair-bonded titi monkeys.Hormones and behavior · 2016Article
- Neurobiological mechanisms of social attachment and pair bonding.Current opinion in behavioral sciences · 2015Article
- Early rearing experience is related to altered aggression and vasopressin production following chronic social isolation in the prairie vole.Behavioural brain research · 2015Article
- μ-Opioid receptors within subregions of the striatum mediate pair bond formation through parallel yet distinct reward mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings.Journal of neurodevelopmental disorders · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The monogamous prairie vole displays developmental sensitivity to early pharmacological manipulation in a number of species-typical social behaviors. The long-term consequences of altering the neonatal dopamine system are not well characterized. This study examined whether early manipulation of the dopamine system, a known mediator of adult prairie vole social behavior, during neonatal development would affect adult aggressive and attachment behaviors. Eight-day-old pups were given a single treatment with either 1 mg/kg of SKF38393 (D1 agonist), quinpirole (D2 agonist), SCH23390 (D1 antagonist), eticlopride (D2 antagonist), or saline vehicle. As adults, animals received tests for intrasexual aggression and partner preference. Activation of D1-like receptors in pups impaired partner preference formation, but had no effect on aggression. Other neonatal treatments had no effect on their behavior as adults. To determine whether D1 activation in pups induced changes in dopamine receptor expression, we performed autoradiography on striatal tissue from a second cohort of saline-treated and SKF38393-treated animals. Although sex differences were observed, we found no treatment differences in D1 or D2 receptor binding in any striatal subregion. This study shows that exposure to a single early pharmacological alteration of dopamine receptor activity may have long-term effects on the social behavior of prairie voles.
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