Evidence map›Paper›PMID 21918121›Full record

ArticleClinical and vaccine immunology : CVI2011

Use of inactivated Escherichia coli enterotoxins to enhance respiratory mucosal adjuvanticity during vaccination in swine.

Roger W Barrette, Steven M Szczepanek, Debra Rood, Sreerupa Challa, Naomi Avery, Michael Vajdy, Ed Kramer, Luis Rodriguez, Lawrence K Silbart

Open access · diamondAbstract read
In one paragraph

Article in Clinical and vaccine immunology : CVI, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Roger W BarretteDepartment of Animal Science, University of Connecticut, Storrs, Connecticut 06269, USA.
Steven M Szczepanek
Debra Rood
Sreerupa Challa
Naomi Avery
Michael Vajdy
Ed Kramer
Luis Rodriguez
Lawrence K Silbart
University of Connecticut · USPlum Island Animal Disease Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In order to augment responses to respiratory vaccines in swine, various adjuvants were intranasally coadministered with a foot-and-mouth disease virus (FMDV) antigen to pigs. Detoxified Escherichia coli enterotoxins LTK63 and LTR72 enhanced antigen-specific mucosal and systemic immunity, demonstrating their efficacy as adjuvants for nonreplicating antigens upon intranasal immunization in swine.

Indexed as

Adjuvants, ImmunologicAdministration, IntranasalAnimalsAntibodies, NeutralizingAntibodies, ViralBacterial ToxinsBloodEnterotoxinsEscherichia coli ProteinsFoot-and-Mouth DiseaseFoot-and-Mouth Disease VirusImmunity, MucosalImmunoglobulin AImmunoglobulin GSwineToxoidsAdjuvants, ImmunologicAntibodies, NeutralizingAntibodies, ViralBacterial ToxinsEnterotoxinsEscherichia coli Proteinsheat-labile enterotoxin, E coliImmunoglobulin AImmunoglobulin GToxoidsViral Vaccines

Identifiers

PMID21918121
PMCPMC3209021
OpenAlexW2110710839

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.