ArticleJournal of neurophysiology2011
Chronic compression of mouse dorsal root ganglion alters voltage-gated sodium and potassium currents in medium-sized dorsal root ganglion neurons.
Article in Journal of neurophysiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 36 citations in OpenAlex.
- Neuromuscular Electrical Stimulation Reduces Leg Cramps in Patients With Lumbar Degenerative Disorders: A Randomized Placebo-Controlled Trial.Neuromodulation : journal of the International Neuromodulation Society · 2021Trial
- Systemic inflammatory perturbations triggered by neuropathic pain in L5 compressed mouse and rat model.Journal of orthopaedic translation · 2026Article
- Advancing Pain Understanding and Drug Discovery: Insights from Preclinical Models and Recent Research Findings.Pharmaceuticals (Basel, Switzerland) · 2024Review
- T-type CaMolecular pain · 2022Article
- Growth Differentiation Factor-15 Produces Analgesia by Inhibiting Tetrodotoxin-Resistant Nav1.8 Sodium Channel Activity in Rat Primary Sensory Neurons.Neuroscience bulletin · 2021Article
- Magnolol attenuates inflammatory pain by inhibiting sodium currents in mouse dorsal root ganglion neurons.Inflammopharmacology · 2021Article
- A double-network hydrogel for the dynamic compression of the lumbar nerve root.Neural regeneration research · 2020Article
- Characteristics of voltage-gated potassium currents in monosodium urate induced gouty arthritis in mice.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020Article
- Role of NaNeuroscience · 2019Article
- The Distributions of Voltage-Gated KThe Journal of membrane biology · 2018Article
- Using dynamic clamp to quantify pathological changes in the excitability of primary somatosensory neurons.The Journal of physiology · 2018Article
- Anti-nociceptive effects of bupivacaine-encapsulated PLGA nanoparticles applied to the compressed dorsal root ganglion in mice.Neuroscience letters · 2018Article
- Inhibitory Effects of Honokiol on the Voltage-Gated Potassium Channels in Freshly Isolated Mouse Dorsal Root Ganglion Neurons.Neurochemical research · 2018Article
- Targeting ALDH2 for Therapeutic Interventions in Chronic Pain-Related Myocardial Ischemic Susceptibility.Theranostics · 2018Article
- Effect of CXCL12/CXCR4 signaling on neuropathic pain after chronic compression of dorsal root ganglion.Scientific reports · 2017Article
- Patch Clamp Recordings on Intact Dorsal Root Ganglia from Adult Rats.Journal of visualized experiments : JoVE · 2016Article
- Enhanced excitability and suppression of A-type K(+) currents in joint sensory neurons in a murine model of antigen-induced arthritis.Scientific reports · 2016Article
- Dexmedetomidine inhibits Tetrodotoxin-resistant Nav1.8 sodium channel activity through Gi/o-dependent pathway in rat dorsal root ganglion neurons.Molecular brain · 2015Article
- Inhibition of Hyperpolarization-Activated Cation Current in Medium-Sized DRG Neurons Contributed to the Antiallodynic Effect of Methylcobalamin in the Rat of a Chronic Compression of the DRG.Neural plasticity · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Chronic compression (CCD) of the dorsal root ganglion (DRG) is a model of human radicular pain produced by intraforaminal stenosis and other disorders affecting the DRG, spinal nerve, or root. Previously, we examined electrophysiological changes in small-diameter lumbar level 3 (L3) and L4 DRG neurons treated with CCD; the present study extends these observations to medium-sized DRG neurons, which mediate additional sensory modalities, both nociceptive and non-nociceptive. Whole-cell patch-clamp recordings were obtained from medium-sized somata in the intact DRG in vitro. Compared with neurons from unoperated control animals, CCD neurons exhibited a decrease in the current threshold for action potential generation. In the CCD group, current densities of TTX-resistant and TTX-sensitive Na(+) current were increased, whereas the density of delayed rectifier voltage-dependent K(+) current was decreased. No change was observed in the transient or "A" current after CCD. We conclude that CCD in the mouse produces hyperexcitability in medium-sized DRG neurons, and the hyperexcitability is associated with an increased density of Na(+) current and a decreased density of delayed rectifier voltage-dependent K(+) current.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.