Evidence map›Paper›PMID 21917993›Full record

ReviewCold Spring Harbor perspectives in biology2011

Extracellular matrix in development: insights from mechanisms conserved between invertebrates and vertebrates.

Nicholas H Brown

Open access · bronzeAbstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 129 citations in OpenAlex.

  1. The role of geometry in morphogenesis.Development (Cambridge, England) · 2026
    Review
  2. Article
  3. Review
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  6. Review
  7. Fibronectin matrix assembly at a glance.Journal of cell science · 2025
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
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  19. Targeting syndecan-1: new opportunities in cancer therapy.American journal of physiology. Cell physiology · 2022
    Review
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Nicholas H BrownThe Gurdon Institute and Department of Physiology, Development, and Neuroscience, University of Cambridge, United Kingdom. n.brown@gurdon.cam.ac.uk
Wellcome/Cancer Research UK Gurdon Institute · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The extracellular matrix (ECM) and its receptors make diverse contributions to development. The ECM comes in a variety of forms, including the more "standard" ECM that is internal to the animal and on the basal side of epithelial sheets, as well as the apical ECM, which is especially elaborated in the invertebrates to form the exoskeleton. ECM proteins accumulate adjacent to particular target tissues in the developing animal by a variety of mechanisms: local synthesis in the target tissue; local synthesis by migrating cells; and secretion from a distant source and capture by the target tissue. The diverse developmental functions of the ECM are discussed, including the generation of a road for cell migration, creation of morphogenetic checkpoints for differentiation, modulation of morphogen gradients, insulation of organs, gluing together cell layers, and providing structure for the organism.

Indexed as

AnimalsCell DifferentiationCell MovementExtracellular MatrixExtracellular Matrix ProteinsInvertebratesModels, BiologicalSignal TransductionVertebratesExtracellular Matrix Proteins

Identifiers

PMID21917993
PMCPMC3225944
OpenAlexW2138300993

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.