ArticleJournal of virology2011
Baculovirus infection induces a DNA damage response that is required for efficient viral replication.
Article in Journal of virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed.
- Beet curly top virus affects vector biology: the first transcriptome analysis of the beet leafhopper.The Journal of general virology · 2024Article
- Ataxia Telangiectasia-Mutated Is Activated but Not Required for Productive Autographa californica Multiple Nucleopolyhedrovirus Infection.Journal of virology · 2022Article
- BmNPV p35 Reduces the Accumulation of Virus-Derived siRNAs and Hinders the Function of siRNAs to Facilitate Viral Infection.Frontiers in immunology · 2022Article
- Advances in the Arms Race Between Silkworm and Baculovirus.Frontiers in immunology · 2021Review
- Host AAA+ ATPase TER94 Plays Critical Roles in Building the Baculovirus Viral Replication Factory and Virion Morphogenesis.Journal of virology · 2020Article
- Ac154 carried out anti-apoptotic role during AcMNPV infection process in the host insect cells.Molecular and cellular biochemistry · 2020Article
- Transcriptome Profiling of the WhiteflyFrontiers in physiology · 2019Article
- The complete genome sequence of a third distinct baculovirus isolated from the true armyworm, Mythimna unipuncta, contains two copies of the lef-7 gene.Virus genes · 2018Article
- Transcriptome profiling of whitefly guts in response to Tomato yellow leaf curl virus infection.Virology journal · 2018Article
- Evidence for a radiation-responsive 'p53 gateway' contributing significantly to the radioresistance of lepidopteran insect cells.Scientific reports · 2018Article
- Quantitative proteomics of Sf21 cells during Baculovirus infection reveals progressive host proteome changes and its regulation by viral miRNA.Scientific reports · 2017Article
- Baculovirus antiapoptotic protein P35 regulated the host apoptosis to enhance virus multiplication.Molecular and cellular biochemistry · 2016Article
- The Baculovirus Antiapoptotic p35 Protein Functions as an Inhibitor of the Host RNA Interference Antiviral Response.Journal of virology · 2015Article
- Insect inhibitor-of-apoptosis (IAP) proteins are negatively regulated by signal-induced N-terminal degrons absent within viral IAP proteins.Journal of virology · 2015Article
- Transcriptome responses of the host Trichoplusia ni to infection by the baculovirus Autographa californica multiple nucleopolyhedrovirus.Journal of virology · 2014Article
- Induced antiviral innate immunity in Drosophila.Current opinion in microbiology · 2014Review
- The baculovirus sulfhydryl oxidase Ac92 (P33) interacts with the Spodoptera frugiperda P53 protein and oxidizes it in vitro.Virology · 2013Article
- Baculovirus F-box protein LEF-7 modifies the host DNA damage response to enhance virus multiplication.Journal of virology · 2013Article
- SfDronc, an initiator caspase involved in apoptosis in the fall armyworm Spodoptera frugiperda.Insect biochemistry and molecular biology · 2013Article
- P53-mediated rapid induction of apoptosis conveys resistance to viral infection in Drosophila melanogaster.PLoS pathogens · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several mammalian viruses have been shown to induce a cellular DNA damage response during replication, and in some cases, this response is required for optimal virus replication. However, nothing is known about whether a DNA damage response is stimulated by DNA viruses in invertebrates. Cell cycle arrest and apoptosis are two of the downstream effects of the DNA damage response, and both are stimulated by baculovirus infection, suggesting a possible relationship between baculoviruses and the DNA damage response. In the study described in this report, we found that replication of the baculovirus Autographa californica M nucleopolyhedrovirus (AcMNPV) in the cell line Sf9, derived from the lepidopteran insect Spodoptera frugiperda, stimulated a DNA damage response, as indicated by an increased abundance of the S. frugiperda P53 protein (SfP53) and phosphorylation of the histone variant protein H2AX. Stimulation of the DNA damage response was dependent on viral DNA replication. Inhibition of the DNA damage response prevented both the increase in SfP53 accumulation and H2AX phosphorylation and also caused a 10- to 100-fold reduction in virus production, along with decreased viral DNA replication and late gene expression. However, silencing of Sfp53 expression by RNA interference did not significantly affect AcMNPV replication or induction of apoptosis by a mutant of AcMNPV lacking the antiapoptotic gene p35, indicating that these processes are not dependent on SfP53 in Sf9 cells.
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