ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
The Wnt/beta-catenin asymmetry pathway patterns the atonal ortholog lin-32 to diversify cell fate in a Caenorhabditis elegans sensory lineage.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 18 citations in OpenAlex.
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- Single-cell transcriptomic profiling ofbioRxiv : the preprint server for biology · 2025Article
- The PVD neuron has male-specific structure and mating function inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Glia Development and Function in the NematodeCold Spring Harbor perspectives in biology · 2024Review
- Piecemeal regulation of convergent neuronal lineages by bHLH transcription factors in Caenorhabditis elegans.Development (Cambridge, England) · 2021Article
- Sexual Dimorphism and Sex Differences inGenetics · 2018Article
- LIN-32/Atonal Controls Oxygen Sensing Neuron Development in Caenorhabditis elegans.Scientific reports · 2017Article
- A bHLH Code for Sexually Dimorphic Form and Function of the C. elegans Somatic Gonad.Current biology : CB · 2017Article
- HES-Mediated Repression of Pten in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2015Article
- Atypical Transcriptional Activation by TCF via a Zic Transcription Factor in C. elegans Neuronal Precursors.Developmental cell · 2015Article
- Tcf7l2 is required for left-right asymmetric differentiation of habenular neurons.Current biology : CB · 2014Article
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2 authors at 1 institution in 1 country.
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Abstract
Each sensory ray of the Caenorhabditis elegans male tail comprises three distinct neuroglial cell types. These three cells descend from a single progenitor, the ray precursor cell, through several rounds of asymmetric division called the ray sublineage. Ray development requires the conserved atonal-family bHLH gene lin-32, which specifies the ray neuroblast and promotes the differentiation of its progeny. However, the mechanisms that allocate specific cell fates among these progeny are unknown. Here we show that the distribution of LIN-32 during the ray sublineage is markedly asymmetric, localizing to anterior daughter cells in two successive cell divisions. The anterior-posterior patterning of LIN-32 expression and of differentiated ray neuroglial fates is brought about by the Wnt/β-catenin asymmetry pathway, including the Wnt ligand LIN-44, its receptor LIN-17, and downstream components LIT-1 (NLK), SYS-1 (β-catenin), and POP-1 (TCF). LIN-32 asymmetry itself has an important role in patterning ray cell fates, because the failure to silence lin-32 expression in posterior cells disrupts development of this branch of the ray sublineage. Together, our results illustrate a mechanism whereby the regulated function of a proneural-class gene in a single neural lineage can both specify a neural precursor and actively pattern the fates of its progeny. Moreover, they reveal a central role for the Wnt/β-catenin asymmetry pathway in patterning neural and glial fates in a simple sensory lineage.
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