ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Vsx1 regulates terminal differentiation of type 7 ON bipolar cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 47 citations in OpenAlex.
- Inducible CreEReNeuro · 2026Article
- Inducible CreERbioRxiv : the preprint server for biology · 2025Article
- Insights into Myopia from Mouse Models.Annual review of vision science · 2024Review
- Mutation ofeLife · 2023Article
- Center-surround interactions underlie bipolar cell motion sensitivity in the mouse retina.Nature communications · 2022Article
- ON than OFF pathway disruption leads to greater deficits in visual function and retinal dopamine signaling.Experimental eye research · 2022Article
- Article
- A human cell atlas of fetal gene expression.Science (New York, N.Y.) · 2020Article
- Vsx1 and Chx10 paralogs sequentially secure V2 interneuron identity during spinal cord development.Cellular and molecular life sciences : CMLS · 2020Article
- Simultaneous deletion ofDevelopment (Cambridge, England) · 2020Article
- Zygotic Vsx1 Plays a Key Role in Defining V2a Interneuron Sub-Lineage by Directly RepressingInternational journal of molecular sciences · 2020Article
- Requirements for Neurogenin2 during mouse postnatal retinal neurogenesis.Developmental biology · 2018Article
- A Dense Starburst Plexus Is Critical for Generating Direction Selectivity.Current biology : CB · 2018Article
- Genetic Control of Rod Bipolar Cell Number in the Mouse Retina.Frontiers in neuroscience · 2018Article
- Maturation arrest in early postnatal sensory receptors by deletion of the miR-183/96/182 cluster in mouse.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Uncoupling of neurogenesis and differentiation during retinal development.The EMBO journal · 2017Article
- Gsg1, Trnp1, and Tmem215 Mark Subpopulations of Bipolar Interneurons in the Mouse Retina.Investigative ophthalmology & visual science · 2017Article
- Article
- Development of synaptic connectivity in the retinal direction selective circuit.Current opinion in neurobiology · 2016Review
- Retinal Circuitry Balances Contrast Tuning of Excitation and Inhibition to Enable Reliable Computation of Direction Selectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Although retinal bipolar cells represent a morphologically well defined population of retinal interneurons, very little is known about the developmental mechanisms that regulate their processing. Furthermore, the identity of specific bipolar cell types that function in distinct visual circuits remains poorly understood. Here, we show that the homeobox gene Vsx1 is expressed in Type 7 ON bipolar cells. In the absence of Vsx1, Type 7 bipolar cells exhibit proper morphological specification but show defects in terminal gene expression. Vsx1 is required for the repression of bipolar cell-specific markers, including Calcium-binding protein 5 and Chx10. This contrasts its genetic requirement as an activator of gene expression in OFF bipolar cells. To assess possible ON signaling defects in Vsx1-null mice, we recorded specifically from ON-OFF directionally selective ganglion cells (DSGCs), which cofasciculate with Type 7 bipolar cell terminals. Vsx1-null ON-OFF DSGCs received more sustained excitatory synaptic input, possibly due to Type 7 bipolar cell defects. Interestingly, in Vsx1-null mice, the directionally selective circuit is functional but compromised. Together, these findings indicate that Vsx1 regulates terminal gene expression in Type 7 bipolar cells and is necessary for proper ON visual signaling within a directionally selective circuit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.