Evidence map›Paper›PMID 21917748›Full record

ArticleAdvances in dental research2011

Translational and clinical applications of salivary diagnostics.

W V Giannobile, J T McDevitt, R S Niedbala, D Malamud

Abstract read
In one paragraph

Article in Advances in dental research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
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  5. Review
  6. Review
  7. Observational
  8. Article
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  14. Article
  15. Correlation between caries activity and salivary microbiota in preschool children.Frontiers in cellular and infection microbiology · 2023
    Article
  16. Article
  17. Anticholinergic medication: Related dry mouth and effects on the salivary glands.Oral surgery, oral medicine, oral pathology and oral radiology · 2021
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

W V GiannobileDepartment of Periodontics, Michigan Center for Oral Health Research, University of Michigan School of Dentistry, Ann Arbor, USA.
J T McDevitt
R S Niedbala
D Malamud

Funding

MICHIGAN INSTITUTE FOR CLINICAL AND HEALTH RESEARCH (MICHR) (UL1): (BPCA)UL1RR024986 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHANLEY, THOMAS P. · 2007 to 2011
$51.2M
Effects of Oral Inflammation on the Levels of Salivary Biomarkers of AMIU01DE017793 · NIDCR · UNIVERSITY OF TEXAS AT AUSTIN · PI MCDEVITT, JOHN T · 2006 to 2012
$13.0M
The Proteomic and Functional Profile of HIV Positive SalivaU19DE018385 · NIDCR · NEW YORK UNIVERSITY · PI MALAMUD, DANIEL · 2007 to 2014
$6.6M
Integrated Microfluidic System for Oral DiagnosticsU01DE014961 · NIDCR · SANDIA CORP-SANDIA NATIONAL LABORATORIES · PI SINGH, ANUP K · 2002 to 2005
$4.2M
Point Detection of Pathogens in Oral Samples via UPTU01DE014964 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI MALAMUD, DANIEL · 2002 to 2005
$4.0M
Saliva Analysis with an Array SensorU01DE015017 · NIDCR · UNIVERSITY OF TEXAS AUSTIN · PI ANSLYN, ERIC V · 2002 to 2005
$3.6M
NCRR NIH HHS UL1 RR024986NCRR NIH HHS UL1RR024986NIDCR NIH HHS U01 DE014961NIDCR NIH HHS U01-DE014961NIDCR NIH HHS U01 DE014964NIDCR NIH HHS U01 DE015017NIDCR NIH HHS U01 DE017793NIDCR NIH HHS U01-DE 14964NIDCR NIH HHS U01 DE15017NIDCR NIH HHS U19 DE018385NIDCR NIH HHS U19-DE 18385
6 · The paper itself

Abstract

There have been significant advances in techniques for the detection of biomarker signals in the oral cavity (e.g., ELISAs for proteins, PCR for RNA and DNA) as well as the engineering and development of microfluidic approaches to make oral-based point-of-care (POC) methods for the diagnosis for both local and systemic conditions a reality. In this section, we focus on three such approaches, namely, periodontal disease management, early markers for systemic diseases, and salivary markers useful for pharmacogenomic studies. Novel approaches using non-invasive, salivary samples and user-friendly devices offer results that are as sensitive and specific as laboratory-based analyses using blood or urine.

Indexed as

Translational Research, BiomedicalBiomarkersCardiovascular DiseasesClinical Chemistry TestsDiagnosis, OralGenetic TestingHumansLab-On-A-Chip DevicesMicrofluidicsPeriodontitisPharmacogeneticsPoint-of-Care SystemsSalivaBiomarkers

Identifiers

PMID21917748
PMCPMC3172998

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.